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PhyMA is a laboratory under the dual supervision of the CNRS (INEE) and the National Museum of Natural History.
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Physiologie moléculaire et adaptation
UMR 7221

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Iannuzzi Vincenzo, Narboux-Nême Nicolas, Lehoczki Andrea, Levi Giovanni & Giuliani Cristina, February 2025 — Stay social, stay young: a bioanthropological outlook on the processes linking sociality and ageing. In modern human societies, social interactions and pro-social behaviours are associated with better individual and collective… GeroScience vol. 47, n° 1, p. 721-744
ISSN
2509-2723
https://dx.doi.org/10.1007/s11357-024-01416-5
Dufour Sylvie, Sachs Laurent, Martin Patrick & Rousseau Karine, 2025 — [Metamorphoses in fishes and their endocrine regulations]. The most emblematic metamorphoses in the animal kingdom remain those of the caterpillar into a butterfly and the tadpole into a… Biologie Aujourd'hui vol. 219, n° 1, p. 37-50
ISSN
2105-0686
https://dx.doi.org/10.1051/jbio/2025002
Ullrich Simon, Leidescher Susanne, Feodorova Yana, Thanisch Katharina, Fini Jean-Baptiste, Kaspers Bernd, Weber Frank, Markova Boyka, Führer Dagmar, Romitti Mirian, Krebs Stefan, Blum Helmut, Leonhardt Heinrich, Costagliola Sabine, Heuer Heike et al., 2025 — Corrigendum: The highly and perpetually upregulated thyroglobulin gene is a hallmark of functional thyrocytes. [This corrects the article DOI: 10.3389/fcell.2023.1265407.]. Frontiers in Cell and Developmental Biology vol. 13, , p. 1571466
ISSN
2296-634X
https://dx.doi.org/10.3389/fcell.2025.1571466
Lötters Stefan, Böning Philipp, Bailon Salvador, Castañeda Jose Daniel Barros, Boistel Renaud, Catenazzi Alessandro, Chaparro Juan C., Chávez Germán, Chujutalli Angel, Coen Laurent, Coloma Luis A., Crawford Andrew J., Culebras Jaime, Martínez Juan Carlos Cusi, Daza Juan Manuel et al., January 2025 — A roadmap for harlequin frog systematics, with a partial revision of Amazonian species related to Atelopus spumarius. Harlequin frogs, genus Atelopus, are a species-rich group of bufonid anurans from the Neotropics with more than 100 species… Zootaxa vol. 5571, n° 1, p. 1-76
ISSN
1175-5334
https://dx.doi.org/10.11646/zootaxa.5571.1.1
Rousseau Karine, Girardot Fabrice, Parmentier Caroline & Tostivint Hervé, 2025 — The Caudal Neurosecretory System: A Still Enigmatic Second Neuroendocrine Complex in Fish. The caudal neurosecretory system (CNSS) is a neuroendocrine complex, whose existence is specific to fishes. In teleosts, it… Neuroendocrinology vol. 115, n° 2, p. 154-194
ISSN
1423-0194
https://dx.doi.org/10.1159/000536270
Goutte Aurélie, Martin Nicolas, Alliot Fabrice, Angelier Frédéric, Blanchouin Arnaud, Costantini David, Lesimple Maxime, Ribout Cécile, Traoré Sira, Villalta Rémi & Blanchoud Hélène, December 2024 — From cells to recapture rates: responses and recovery of a wild fish after an experimental exposure to a widely used herbicide. Environmental Science and Pollution Research , ,
ISSN
1614-7499
https://dx.doi.org/10.1007/s11356-024-35837-8
Chamas Lamis, Seugnet Isabelle, Tanvé Odessa, Enderlin Valérie & Clerget-Froidevaux Marie-Stéphanie, October 2024 — The Downregulation of the Liver Lipid Metabolism Induced by Hypothyroidism in Male Mice: Metabolic Flexibility Favors Compensatory Mechanisms in White Adipose Tissue. In mammals, the maintenance of energy homeostasis relies on complex mechanisms requiring tight synchronization between… Int. J. Mol. Sci. vol. 25, n° 19, p. 10792
ISSN
1422-0067
https://dx.doi.org/10.3390/ijms251910792
Djebar Morgane, Anselme Isabelle, Pezeron Guillaume, Bardet Pierre-Luc, Cantaut-Belarif Yasmine, Eschstruth Alexis, López-Santos Diego, Le Ribeuz Hélène, Jenett Arnim, Khoury Hanane, Veziers Joelle, Parmentier Caroline, Hirschler Aurélie, Carapito Christine, Bachmann-Gagescu Ruxandra et al., October 2024 — Astrogliosis and neuroinflammation underlie scoliosis upon cilia dysfunction. Cilia defects lead to scoliosis in zebrafish, but the underlying pathogenic mechanisms are poorly understood and may diverge… eLife vol. 13, , RP96831
ISSN
2050-084X
https://dx.doi.org/10.7554/eLife.96831.3
Pesce Elise, Benitez-Gonzalez Jessica, Tindall Andrew J., Lemkine Gregory F., Robin-Duchesne Barbara, Sachs Laurent M. & Pasquier Et David Du, September 2024 — Testing the sensitivity of the medaka Transgenic Eleuthero-embryonic THYroid-Specific assay (TETHYS) to different mechanisms of action. There are many concerns about the impacts of Endocrine-Disrupting Chemicals on both wildlife and human populations. A plethora… vol. 276, , p. 107081
ISSN
1879-1514
https://dx.doi.org/10.1016/j.aquatox.2024.107081
Louis Emeric, Fu Liezhen, Shi Yun-Bo & Sachs Laurent M, September 2024 — Functions and Mechanism of Thyroid Hormone Receptor Action During Amphibian Development. Abstract Thyroid hormones and their receptors (TRs) play critical roles during vertebrate development. One of the most dramatic… Endocrinology vol. 165, n° 11, bqae137
ISSN
1945-7170
https://dx.doi.org/10.1210/endocr/bqae137
Aouci Rym, Fontaine Anastasia, Vion Amïn, Belz Lou, Levi Giovanni & Narboux-Nême Nicolas, July 2024 — The Antidepressant Action of Fluoxetine Involves the Inhibition of Dlx5/6 in Cortical GABAergic Neurons through a TrkB-Dependent Pathway. Major depressive disorder (MDD) is a complex and devastating illness that affects people of all ages. Despite the large use of… Cells vol. 13, n° 15, p. 1262
ISSN
2073-4409
https://dx.doi.org/10.3390/cells13151262
Valcárcel-Hernández Víctor, Vancamp Pieter, Butruille Lucile, Remaud Sylvie & Guadaño-Ferraz Ana, June 2024 — Combined deletion of Mct8 and Dio2 impairs SVZ neurogliogenesis and olfactory function in adult mice. Within the adult mouse subventricular zone (SVZ), neural stem cells (NSCs) produce neuroblasts and oligodendrocyte precursor… Neurobiology of Disease vol. 199, , p. 106572
ISSN
1095-953X
https://dx.doi.org/10.1016/j.nbd.2024.106572
Chevalier Nicolas, Guillou Pauline, Viguié Catherine, Fini Jean-Baptiste, Sachs Laurent M., Michel-Caillet Cécile & Mhaouty-Kodja Sakina, June 2024 — Lithium and endocrine disruption: A concern for human health?. Lithium is a key medication for the treatment of psychiatric disorders and is also used in various industrial applications … Environment International , , p. 108861
ISSN
1873-6750
https://dx.doi.org/10.1016/j.envint.2024.108861
Tribondeau Alicia, Du Pasquier David, Benchouaia Médine, Blugeon Corinne, Buisine Nicolas & Sachs Laurent M., March 2024 — Overlapping action of T3 and T4 during Xenopus laevis development. Thyroid hormones are involved in many biological processes such as neurogenesis, metabolism, and development. However,… Frontiers in Endocrinology vol. 15, , p. 1360188
ISSN
1664-2392
https://dx.doi.org/10.3389/fendo.2024.1360188
Vom Saal Frederick S., Antoniou Michael, Belcher Scott M., Bergman Ake, Bhandari Ramji K., Birnbaum Linda S., Cohen Aly, Collins Terrence J., Demeneix Barbara, Fine Anne Marie, Flaws Jodi A., Gayrard Veronique, Goodson William H., Gore Andrea C., Heindel Jerrold J. et al., March 2024 — The Conflict between Regulatory Agencies over the 20,000-Fold Lowering of the Tolerable Daily Intake (TDI) for Bisphenol A (BPA) by the European Food Safety Authority (EFSA). BACKGROUND: The European Food Safety Authority (EFSA) recommended lowering their estimated tolerable daily intake (TDI) for… Environmental Health Perspectives vol. 132, n° 4, p. 45001
ISSN
1552-9924
https://dx.doi.org/10.1289/EHP13812
Valcárcel-Hernández Victor, Mayerl Steffen, Guadaño-Ferraz Ana & Remaud Sylvie, 2024 — Thyroid hormone action in adult neurogliogenic niches: the known and unknown. Over the last decades, thyroid hormones (THs) signaling has been established as a key signaling cue for the proper maintenance… Frontiers in Endocrinology vol. 15, , p. 1347802
ISSN
1664-2392
https://dx.doi.org/10.3389/fendo.2024.1347802
Anoud M., Delagoutte E., Helleu Q., Brion A., Duvernois-Berthet E., As M., Marques X., Lamribet K., Senamaud C., Jourdren L., Adrait A., Heinrich S., Toutirais G., Hamlaoui S., Gropplero G. et al., January 2024 — Comparative transcriptomics reveal a novel tardigrade specific DNA binding protein induced in response to ionizing radiation. Tardigrades, microscopic animals found in virtually all ecosystems, are renowned for their remarkable ability to withstand… eLife , ,
https://dx.doi.org/10.7554/eLife.92621.1
Mayeux Franck, Buisine Nicolas, Fayol Olivier & Uguen Patricia, 2024 — Transcriptional activation of candidate paused genes after partial hepatectomy. Partial hepatectomy is a model of acute liver injury that is known to induce a strong reprogrammation of gene expression… microPublication Biology vol. 2024, ,
ISSN
2578-9430
https://dx.doi.org/10.17912/micropub.biology.001160
Bredeson Jessen V., Mudd Austin B., Medina-Ruiz Sofia, Mitros Therese, Smith Owen Kabnick, Miller Kelly E., Lyons Jessica B., Batra Sanjit S., Park Joseph, Berkoff Kodiak C., Plott Christopher, Grimwood Jane, Schmutz Jeremy, Aguirre-Figueroa Guadalupe, Khokha Mustafa K. et al., January 2024 — Conserved chromatin and repetitive patterns reveal slow genome evolution in frogs. Frogs are an ecologically diverse and phylogenetically ancient group of anuran amphibians that include important vertebrate… Nat. Commun. vol. 15, n° 1, p. 579
ISSN
2041-1723
https://dx.doi.org/10.1038/s41467-023-43012-9
Fénichel Patrick, Todaka Emiko, Etzel Ruth A., Chan Chang-Chuan, Barouki Robert, Chevalier Nicolas, Fini Jean-Baptiste, Poore Kirsten R., Sakabe Kou, Siroux Valerie, Yamamoto Midori & Mori Chisato, 2024 — Call to introduce environmental preventive medicine courses to the medical curriculum. An initial experience of an education program at the Faculty of Medicine of Nice, University of Côte d’Azur. Frontiers in Medicine vol. 11, , p. 1412674
ISSN
2296-858X
https://dx.doi.org/10.3389/fmed.2024.1412674
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