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PhyMA is a laboratory under the dual supervision of the CNRS (INEE) and the National Museum of Natural History.
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Physiologie moléculaire et adaptation
UMR 7221

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Elagali Ahmed, Rüegg Joëlle, Caporale Nicolò, Testa Giuseppe, Sapounidou Maria, Fini Jean-Baptiste, Andersson Patrik L., Dunlop Sarah, Bornehag Carl-Gustaf & Gennings Chris, March 2026 — From correlation to causation: Integrating cohorts with experimental studies in mixture toxicology. Harmful chemical mixtures are pervasive in the environment, yet traditional epidemiological designs face major challenges in… Neurotoxicology vol. 113, , p. 103399
ISSN
1872-9711
https://dx.doi.org/10.1016/j.neuro.2026.103399
Rannaud-Bartaire Patricia, Herranen Anni, Levi Giovanni, Demeneix Barbara & Fini Jean-Baptiste, March 2026 — Environmental challenges to thyroid homeostasis: Combined effects of iodine deficiency and endocrine disruption. Current Opinion in Endocrine and Metabolic Research vol. 42, , p. 100597
ISSN
24519650
https://dx.doi.org/10.1016/j.coemr.2026.100597
Ardenkjær-Skinnerup Jacob, Baert Yoni, Bajard Lola, Blum Jonathan, Brion François, Coppola Lucia, Fini Jean-Baptiste, Fritsche Ellen, Holbech Henrik, Hurem Selma, Jacobs Miriam Naomi, Johansson Hanna Katarina Lilith, Knapen Dries, Koch Katharina, Lyche Jan Ludvig et al., 2026 — New approach methodologies (NAMs) for improved developmental and reproductive toxicity (DART) assessment with focus on endocrine disruption - a PARC project. Endocrine disruptors (EDs) are implicated in adverse developmental and reproductive outcomes, yet their identification remains… Frontiers in Toxicology vol. 8, , p. 1736963
ISSN
2673-3080
https://dx.doi.org/10.3389/ftox.2026.1736963
Herranen Anni, Rannaud-Bartaire Patricia, Escoube Raphaëlle, Manoury Annabelle, Bouvier-Capely Céline & Fini Jean-Baptiste, January 2026 — A pilot study to develop a murine model of iodine deficiency using sodium perchlorate exposure. Abstract Objective Moderate iodine deficiency is common worldwide and its health consequences are not fully understood. To… Environmental Endocrinology vol. 2, n° 1, wkag004
ISSN
3049-7442
https://dx.doi.org/10.1093/enendo/wkag004
European Food Safety Authority (EFSA) and Baumann Lisa, Baynes Alice, Bennekou Susanne Hougaard, Crofton Kevin, Dang Zhichao, Degitz Sigmund, Fini Jean-Baptiste, Gilbert Mary, Holbech Henrik, Terron Andrea, Van Duursen Majorie, McVey Emily, Arena Maria, Kienzler Aude, Rizzuto Simone et al., December 2025 — The assessment for potential thyroid-mediated endocrine disruption in amphibians: Clarification on the use of new methods and on the interpretation of changes in thyroid histology. Amphibians (specifically Xenopus laevis) are used as the model species to assess potential endocrine-disrupting properties in… EFSA journal. European Food Safety Authority vol. 23, n° 12, e9815
ISSN
1831-4732
https://dx.doi.org/10.2903/j.efsa.2025.9815
Herranen Anni, Rannaud-Bartaire Patricia & Fini Jean-Baptiste, June 2025 — The thyroid hormone system and its disruption. Annales D’endocrinologie vol. 86, n° 3, p. 101773
ISSN
2213-3941
https://dx.doi.org/10.1016/j.ando.2025.101773
Krief Sabrina, Spirhanzlova Petra & Fini Jean-Baptiste, June 2025 — Crisis on the Planet of the Apes-Plastic, the new threat?. INTRODUCTION: Chimpanzees, our closest relatives, are threatened with extinction by poaching, zoonoses, fragmentation and the… Annales D’endocrinologie vol. 86, n° 3, p. 101778
ISSN
2213-3941
https://dx.doi.org/10.1016/j.ando.2025.101778
Ullrich Simon, Leidescher Susanne, Feodorova Yana, Thanisch Katharina, Fini Jean-Baptiste, Kaspers Bernd, Weber Frank, Markova Boyka, Führer Dagmar, Romitti Mirian, Krebs Stefan, Blum Helmut, Leonhardt Heinrich, Costagliola Sabine, Heuer Heike et al., 2025 — Corrigendum: The highly and perpetually upregulated thyroglobulin gene is a hallmark of functional thyrocytes. [This corrects the article DOI: 10.3389/fcell.2023.1265407.]. Frontiers in Cell and Developmental Biology vol. 13, , p. 1571466
ISSN
2296-634X
https://dx.doi.org/10.3389/fcell.2025.1571466
Chevalier Nicolas, Guillou Pauline, Viguié Catherine, Fini Jean-Baptiste, Sachs Laurent M., Michel-Caillet Cécile & Mhaouty-Kodja Sakina, June 2024 — Lithium and endocrine disruption: A concern for human health?. Lithium is a key medication for the treatment of psychiatric disorders and is also used in various industrial applications … Environment International , , p. 108861
ISSN
1873-6750
https://dx.doi.org/10.1016/j.envint.2024.108861
Fénichel Patrick, Todaka Emiko, Etzel Ruth A., Chan Chang-Chuan, Barouki Robert, Chevalier Nicolas, Fini Jean-Baptiste, Poore Kirsten R., Sakabe Kou, Siroux Valerie, Yamamoto Midori & Mori Chisato, 2024 — Call to introduce environmental preventive medicine courses to the medical curriculum. An initial experience of an education program at the Faculty of Medicine of Nice, University of Côte d’Azur. Frontiers in Medicine vol. 11, , p. 1412674
ISSN
2296-858X
https://dx.doi.org/10.3389/fmed.2024.1412674
Rannaud-Bartaire Patricia, Demeneix Barbara A. & Fini Jean-Baptiste, December 2023 — Pressures of the urban environment on the endocrine system: Adverse effects and adaptation. With an increasing collective awareness of the rapid environmental changes, questions and theories regarding the adaptability… Mol. Cell. Endocrinol. , , p. 112125
ISSN
1872-8057
https://dx.doi.org/10.1016/j.mce.2023.112125
Spirhanzlova Petra, Couderq Stephan, Le Mével Sébastian, Leemans Michelle, Krief Sabrina, Mughal Bilal B., Demeneix Barbara A. & Fini Jean-Baptiste, June 2023 — Short and long term effects of chlorpyrifos on thyroid hormone axis and brain development in Xenopus laevis. INTRODUCTION: The extensive use of the insecticide chlorpyrifos (CPF) throughout the world has brought increased scrutiny on… Neuroendocrinology vol. 113, n° 12, p. 1298-1311
ISSN
1423-0194
https://dx.doi.org/10.1159/000525719
Sapounidou Maria, Andersson Patrik L., Leemans Michelle, Fini Jean-Baptiste, Demeneix Barbara, Rüegg Joëlle, Bornehag Carl-Gustaf & Gennings Chris, March 2023 — From Cohort to Cohort: A Similar Mixture Approach (SMACH) to Evaluate Exposures to a Mixture Leading to Thyroid-Mediated Neurodevelopmental Effects Using NHANES Data. Prenatal exposure to a mixture (MIX N) of eight endocrine-disrupting chemicals has been associated with language delay in… Toxics vol. 11, n° 4, p. 331
ISSN
2305-6304
https://dx.doi.org/10.3390/toxics11040331
Pasquier Elodie, Viguié Catherine, Fini Jean-Baptiste, Mhaouty-Kodja Sakina & Michel-Caillet Cécile, March 2023 — Limits of the regulatory evaluation of resorcinol as a thyroid disruptor: When limited experimental data challenge established effects in humans. Severe hypothyroidism has been reported in humans during resorcinol therapeutic use. However, available data highlight… Environ Res vol. 222, , p. 115330
ISSN
1096-0953
https://dx.doi.org/10.1016/j.envres.2023.115330
Rodríguez-Carrillo Andrea, Mustieles Vicente, Salamanca-Fernández Elena, Olivas-Martínez Alicia, Suárez Beatriz, Bajard Lola, Baken Kirsten, Blaha Ludek, Bonefeld-Jørgensen Eva Cecilie, Couderq Stephan, D’Cruz ShereenCynthia, Fini Jean-Baptiste, Govarts Eva, Gundacker Claudia, Hernández Antonio F. et al., February 2023 — Implementation of effect biomarkers in human biomonitoring studies: A systematic approach synergizing toxicological and epidemiological knowledge. Human biomonitoring (HBM) studies have highlighted widespread daily exposure to environmental chemicals. Some of these are… Int J Hyg Environ Health vol. 249, , p. 114140
ISSN
1618-131X
https://dx.doi.org/10.1016/j.ijheh.2023.114140
Ullrich Simon, Leidescher Susanne, Feodorova Yana, Thanisch Katharina, Fini Jean-Baptiste, Kaspers Bernd, Weber Frank, Markova Boyka, Führer Dagmar, Romitti Mirian, Krebs Stefan, Blum Helmut, Leonhardt Heinrich, Costagliola Sabine, Heuer Heike et al., 2023 — The highly and perpetually upregulated thyroglobulin gene is a hallmark of functional thyrocytes. Abnormalities are indispensable for studying normal biological processes and mechanisms. In the present work, we draw attention… vol. 11, , p. 1265407
ISSN
2296-634X
https://dx.doi.org/10.3389/fcell.2023.1265407
Rannaud-Bartaire Patricia & Fini Jean-Baptiste, 2023 — [Disruptors of thyroid hormones: Which consequences for human health and environment?]. Endocrine disruptors (EDs) of chemical origin are the subject of numerous studies, some of which have led to measures aimed at… Bioogie Aujourd'hui vol. 217, n° 3, p. 219-231
ISSN
2105-0686
https://dx.doi.org/10.1051/jbio/2023036
Leemans Michelle, Spirhanzlova Petra, Couderq Stephan, LeMével Sébastien, Grimaldi Alexis, Duvernois-Berthet Evelyne, Demeneix Barbara & Fini Jean-Baptiste, January 2023 — A Mixture of Chemicals Found in Human Amniotic Fluid Disrupts Brain Gene Expression and Behavior in Xenopus laevis. Thyroid hormones (TH) are essential for normal brain development, influencing neural cell differentiation, migration, and… Int J Mol Sci. vol. 24, n° 3, p. 2588
ISSN
1422-0067
https://dx.doi.org/10.3390/ijms24032588
Vancamp Pieter, Butruille Lucile, Herranen Anni, Boelen Anita, Fini Jean-Baptiste, Demeneix Barbara A. & Remaud Sylvie, January 2023 — Transient developmental exposure to low doses of bisphenol F negatively affects neurogliogenesis and olfactory behaviour in adult mice. Neural stem cells in the murine subventricular zone (SVZ) reactivate during postnatal development to generate neurons and glia… Environ Int . vol. 172, , p. 107770
ISSN
1873-6750
https://dx.doi.org/10.1016/j.envint.2023.107770
Andersen Helle Raun, David Arthur, Freire Carmen, Fernández Mariana F., D’Cruz Shereen Cynthia, Reina-Pérez Iris, Fini Jean-Baptiste & Blaha Ludek, November 2022 — Pyrethroids and developmental neurotoxicity - A critical review of epidemiological studies and supporting mechanistic evidence. BACKGROUND : Pyrethroid metabolites are widely detectable in urine from the general population, including pregnant women and… Environmental Research vol. 214, , p. 113935
ISSN
1096-0953
https://dx.doi.org/10.1016/j.envres.2022.113935
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