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PhyMA is a laboratory under the dual supervision of the CNRS (INEE) and the National Museum of Natural History.
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Physiologie moléculaire et adaptation
UMR 7221

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Butruille L., Guittonneau C., Le Blay K., Valcarcel V., Aigrot M. S., Fini J. B., Zalc B. & Remaud S., July 2026 — Early-life PFOS exposure causes lasting impairment of neural stem cell fate, white matter maturation, and olfactory behavior. Per- and polyfluoroalkyl substances (PFAS) are widespread and persistent environmental pollutants that bioaccumulate and are… Ecotoxicol Environ Saf vol. 320, , p. 120365
ISSN
1090-2414
https://dx.doi.org/10.1016/j.ecoenv.2026.120365
Samee Nadeem, Belz Lou, Narboux-Nême Nicolas, Roux Jean-Christophe, Panayotis Nicolas & Levi Giovanni, May 2026 — Increased Osteoclast Activity Contributes to Bone Resorption and Osteopenia in a Rett Syndrome Mouse Model. Rett syndrome is a severe neurodevelopmental disorder caused predominantly by loss-of-function mutations in the X-linked gene… Cells vol. 15, n° 10, p. 948
ISSN
2073-4409
https://dx.doi.org/10.3390/cells15100948
Rannaud-Bartaire Patricia, Herranen Anni, Levi Giovanni, Demeneix Barbara & Fini Jean-Baptiste, March 2026 — Environmental challenges to thyroid homeostasis: Combined effects of iodine deficiency and endocrine disruption. Current Opinion in Endocrine and Metabolic Research vol. 42, , p. 100597
ISSN
24519650
https://dx.doi.org/10.1016/j.coemr.2026.100597
Herranen Anni, Rannaud-Bartaire Patricia, Escoube Raphaëlle, Manoury Annabelle, Bouvier-Capely Céline & Fini Jean-Baptiste, January 2026 — A pilot study to develop a murine model of iodine deficiency using sodium perchlorate exposure. Abstract Objective Moderate iodine deficiency is common worldwide and its health consequences are not fully understood. To… Environmental Endocrinology vol. 2, n° 1, wkag004
ISSN
3049-7442
https://dx.doi.org/10.1093/enendo/wkag004
Valcarcel-Hernandez V., Butruille L. & Remaud S., December 2025 — Effects of thyroid disruption on neural cells stem fate in the mouse brain. Thyroid hormones (THs), particularly T3 and T4, play crucial roles in neural development and maintenance by regulating neural… Presse Medicale vol. 54, n° 4, p. 104312
ISSN
2213-0276
https://dx.doi.org/10.1016/j.lpm.2025.104312
Toussaint-Lardé Isabelle, Louppe Vivien, Sanchez-Garrido Frida, Taillades Morgane, Amine Ryadh, Mandica Mark, Heude Eglantine, Herrel Anthony & Fabre Anne-Claire, July 2025 — The impact of size and ontogeny on suction feeding kinematics in the axolotl (Ambystoma mexicanum). Size impacts all aspects of life in animals. Not only does it impact metabolism and physiology, it also affects movements,… Biology Open vol. 14, n° 7, bio061860
ISSN
2046-6390
https://dx.doi.org/10.1242/bio.061860
Herranen Anni, Rannaud-Bartaire Patricia & Fini Jean-Baptiste, June 2025 — The thyroid hormone system and its disruption. Annales D’endocrinologie vol. 86, n° 3, p. 101773
ISSN
2213-3941
https://dx.doi.org/10.1016/j.ando.2025.101773
Iannuzzi Vincenzo, Narboux-Nême Nicolas, Lehoczki Andrea, Levi Giovanni & Giuliani Cristina, February 2025 — Stay social, stay young: a bioanthropological outlook on the processes linking sociality and ageing. In modern human societies, social interactions and pro-social behaviours are associated with better individual and collective… GeroScience vol. 47, n° 1, p. 721-744
ISSN
2509-2723
https://dx.doi.org/10.1007/s11357-024-01416-5
Goutte Aurélie, Martin Nicolas, Alliot Fabrice, Angelier Frédéric, Blanchouin Arnaud, Costantini David, Lesimple Maxime, Ribout Cécile, Traoré Sira, Villalta Rémi & Blanchoud Hélène, December 2024 — From cells to recapture rates: responses and recovery of a wild fish after an experimental exposure to a widely used herbicide. Environmental Science and Pollution Research , ,
ISSN
1614-7499
https://dx.doi.org/10.1007/s11356-024-35837-8
Chamas Lamis, Seugnet Isabelle, Tanvé Odessa, Enderlin Valérie & Clerget-Froidevaux Marie-Stéphanie, October 2024 — The Downregulation of the Liver Lipid Metabolism Induced by Hypothyroidism in Male Mice: Metabolic Flexibility Favors Compensatory Mechanisms in White Adipose Tissue. In mammals, the maintenance of energy homeostasis relies on complex mechanisms requiring tight synchronization between… Int. J. Mol. Sci. vol. 25, n° 19, p. 10792
ISSN
1422-0067
https://dx.doi.org/10.3390/ijms251910792
Aouci Rym, Fontaine Anastasia, Vion Amïn, Belz Lou, Levi Giovanni & Narboux-Nême Nicolas, July 2024 — The Antidepressant Action of Fluoxetine Involves the Inhibition of Dlx5/6 in Cortical GABAergic Neurons through a TrkB-Dependent Pathway. Major depressive disorder (MDD) is a complex and devastating illness that affects people of all ages. Despite the large use of… Cells vol. 13, n° 15, p. 1262
ISSN
2073-4409
https://dx.doi.org/10.3390/cells13151262
Valcárcel-Hernández Víctor, Vancamp Pieter, Butruille Lucile, Remaud Sylvie & Guadaño-Ferraz Ana, June 2024 — Combined deletion of Mct8 and Dio2 impairs SVZ neurogliogenesis and olfactory function in adult mice. Within the adult mouse subventricular zone (SVZ), neural stem cells (NSCs) produce neuroblasts and oligodendrocyte precursor… Neurobiology of Disease vol. 199, , p. 106572
ISSN
1095-953X
https://dx.doi.org/10.1016/j.nbd.2024.106572
Valcárcel-Hernández Victor, Mayerl Steffen, Guadaño-Ferraz Ana & Remaud Sylvie, 2024 — Thyroid hormone action in adult neurogliogenic niches: the known and unknown. Over the last decades, thyroid hormones (THs) signaling has been established as a key signaling cue for the proper maintenance… Frontiers in Endocrinology vol. 15, , p. 1347802
ISSN
1664-2392
https://dx.doi.org/10.3389/fendo.2024.1347802
Krief Sabrina, Spirhanzlova Petra, Masi Shelly, Couturier Chloé, Okwir Eric, Asalu Edward, Bustamante Paco & Costantini David, November 2023 — High urinary oxidative DNA damage in wild chimpanzees ranging in proximity of agricultural fields in Sebitoli area, Uganda. Agriculture expansion is a major cause of habitat loss and exposure to phytochemical pollution for non-human primates. In… vol. 30, n° 51, p. 110600-110611
ISSN
1614-7499
https://dx.doi.org/10.1007/s11356-023-30187-3
Butruille L., Jubin P., Martin E., Aigrot M. S., Lhomme M., Fini J. B., Demeneix B., Stankoff B., Lubetzki C., Zalc B. & Remaud S., September 2023 — Deleterious functional consequences of perfluoroalkyl substances accumulation into the myelin sheath. Exposure to persistent organic pollutants during the perinatal period is of particular concern because of the potential… vol. 180, , p. 108211
ISSN
1873-6750
https://dx.doi.org/10.1016/j.envint.2023.108211
Vancamp Pieter & Remaud Sylvie, March 2023 — Developmental exposure to thyroid disruptors: misprogramming of the brain’s stem cells in later life?. Neural Regen Res vol. 18, n° 3, p. 527-528
ISSN
1673-5374
https://dx.doi.org/10.4103/1673-5374.346053
Butruille Lucile, Sébillot Anthony, Ávila Katia, Vancamp Pieter, Demeneix Barbara A., Pifferi Fabien & Remaud Sylvie, February 2023 — Increased oligodendrogenesis and myelination in the subventricular zone of aged mice and gray mouse lemurs. The adult rodent subventricular zone (SVZ) generates neural stem cells (NSCs) throughout life that migrate to the olfactory… Stem Cell Reports vol. 18, n° 2, p. 534-554
ISSN
2213-6711
https://dx.doi.org/10.1016/j.stemcr.2022.12.015
Vancamp Pieter, Butruille Lucile, Herranen Anni, Boelen Anita, Fini Jean-Baptiste, Demeneix Barbara A. & Remaud Sylvie, January 2023 — Transient developmental exposure to low doses of bisphenol F negatively affects neurogliogenesis and olfactory behaviour in adult mice. Neural stem cells in the murine subventricular zone (SVZ) reactivate during postnatal development to generate neurons and glia… Environ Int . vol. 172, , p. 107770
ISSN
1873-6750
https://dx.doi.org/10.1016/j.envint.2023.107770
Levi Giovanni, Narboux-Nême Nicolas & Cohen-Solal Martine, October 2022 — DLX Genes in the Development and Maintenance of the Vertebrate Skeleton: Implications for Human Pathologies. Skeletal shape and mechanical properties define, to a large extent, vertebrate morphology and physical capacities. During… Cells vol. 11, n° 20, p. 3277
ISSN
2073-4409
https://dx.doi.org/10.3390/cells11203277
Chamas Lamis, Seugnet Isabelle, Poirier Roseline, Clerget-Froidevaux Marie-Stéphanie & Enderlin Valérie, October 2022 — A Fine Regulation of the Hippocampal Thyroid Signalling Protects Hypothyroid Mice against Glial Cell Activation. Adult-onset hypothyroidism is associated with learning and cognitive dysfunctions, which may be related to alterations in… International Journal of Molecular Sciences vol. 23, n° 19, p. 11938
ISSN
1422-0067
https://dx.doi.org/10.3390/ijms231911938
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  • Gladys ALFAMA
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