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PhyMA est une Unité Mixte de Recherche CNRS-MNHN (UMR 7221).
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Physiologie moléculaire et adaptation
UMR 7221

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Chamas Lamis, Seugnet Isabelle, Tanvé Odessa, Enderlin Valérie & Clerget-Froidevaux Marie-Stéphanie, octobre 2024 — The Downregulation of the Liver Lipid Metabolism Induced by Hypothyroidism in Male Mice: Metabolic Flexibility Favors Compensatory Mechanisms in White Adipose Tissue. In mammals, the maintenance of energy homeostasis relies on complex mechanisms requiring tight synchronization between… Int. J. Mol. Sci. vol. 25, n° 19, p. 10792
ISSN
1422-0067
https://dx.doi.org/10.3390/ijms251910792
Aouci Rym, Fontaine Anastasia, Vion Amïn, Belz Lou, Levi Giovanni & Narboux-Nême Nicolas, juillet 2024 — The Antidepressant Action of Fluoxetine Involves the Inhibition of Dlx5/6 in Cortical GABAergic Neurons through a TrkB-Dependent Pathway. Major depressive disorder (MDD) is a complex and devastating illness that affects people of all ages. Despite the large use of… Cells vol. 13, n° 15, p. 1262
ISSN
2073-4409
https://dx.doi.org/10.3390/cells13151262
Valcárcel-Hernández Víctor, Vancamp Pieter, Butruille Lucile, Remaud Sylvie & Guadaño-Ferraz Ana, juillet 2024 — Combined deletion of Mct8 and Dio2 impairs SVZ neurogliogenesis and olfactory function in adult mice. Within the adult mouse subventricular zone (SVZ), neural stem cells (NSCs) produce neuroblasts and oligodendrocyte precursor… Neurobiology of Disease vol. 199, , p. 106572
ISSN
1095-953X
https://dx.doi.org/10.1016/j.nbd.2024.106572
Valcárcel-Hernández Victor, Mayerl Steffen, Guadaño-Ferraz Ana & Remaud Sylvie, 2024 — Thyroid hormone action in adult neurogliogenic niches: the known and unknown. Over the last decades, thyroid hormones (THs) signaling has been established as a key signaling cue for the proper maintenance… Frontiers in Endocrinology vol. 15, , p. 1347802
ISSN
1664-2392
https://dx.doi.org/10.3389/fendo.2024.1347802
Krief Sabrina, Spirhanzlova Petra, Masi Shelly, Couturier Chloé, Okwir Eric, Asalu Edward, Bustamante Paco & Costantini David, décembre 2023 — High urinary oxidative DNA damage in wild chimpanzees ranging in proximity of agricultural fields in Sebitoli area, Uganda. Agriculture expansion is a major cause of habitat loss and exposure to phytochemical pollution for non-human primates. In… vol. 30, n° 51, p. 110600-110611
ISSN
1614-7499
https://dx.doi.org/10.1007/s11356-023-30187-3
Butruille L., Jubin P., Martin E., Aigrot M. S., Lhomme M., Fini J. B., Demeneix B., Stankoff B., Lubetzki C., Zalc B. & Remaud S., octobre 2023 — Deleterious functional consequences of perfluoroalkyl substances accumulation into the myelin sheath. Exposure to persistent organic pollutants during the perinatal period is of particular concern because of the potential… vol. 180, , p. 108211
ISSN
1873-6750
https://dx.doi.org/10.1016/j.envint.2023.108211
Vancamp Pieter & Remaud Sylvie, mars 2023 — Developmental exposure to thyroid disruptors: misprogramming of the brain’s stem cells in later life?. Neural Regen Res vol. 18, n° 3, p. 527-528
ISSN
1673-5374
https://dx.doi.org/10.4103/1673-5374.346053
Butruille Lucile, Sébillot Anthony, Ávila Katia, Vancamp Pieter, Demeneix Barbara A., Pifferi Fabien & Remaud Sylvie, mars 2023 — Increased oligodendrogenesis and myelination in the subventricular zone of aged mice and gray mouse lemurs. The adult rodent subventricular zone (SVZ) generates neural stem cells (NSCs) throughout life that migrate to the olfactory… Stem Cell Reports vol. 18, n° 2, p. 534-554
ISSN
2213-6711
https://dx.doi.org/10.1016/j.stemcr.2022.12.015
Vancamp Pieter, Butruille Lucile, Herranen Anni, Boelen Anita, Fini Jean-Baptiste, Demeneix Barbara A. & Remaud Sylvie, janvier 2023 — Transient developmental exposure to low doses of bisphenol F negatively affects neurogliogenesis and olfactory behaviour in adult mice. Neural stem cells in the murine subventricular zone (SVZ) reactivate during postnatal development to generate neurons and glia… Environ Int . vol. 172, , p. 107770
ISSN
1873-6750
https://dx.doi.org/10.1016/j.envint.2023.107770
Levi Giovanni, Narboux-Nême Nicolas & Cohen-Solal Martine, octobre 2022 — DLX Genes in the Development and Maintenance of the Vertebrate Skeleton: Implications for Human Pathologies. Skeletal shape and mechanical properties define, to a large extent, vertebrate morphology and physical capacities. During… Cells vol. 11, n° 20, p. 3277
ISSN
2073-4409
https://dx.doi.org/10.3390/cells11203277
Chamas Lamis, Seugnet Isabelle, Poirier Roseline, Clerget-Froidevaux Marie-Stéphanie & Enderlin Valérie, octobre 2022 — A Fine Regulation of the Hippocampal Thyroid Signalling Protects Hypothyroid Mice against Glial Cell Activation. Adult-onset hypothyroidism is associated with learning and cognitive dysfunctions, which may be related to alterations in… International Journal of Molecular Sciences vol. 23, n° 19, p. 11938
ISSN
1422-0067
https://dx.doi.org/10.3390/ijms231911938
Sebastiano Manrico, Costantini David, Eens Marcel, Pineau Kevin, Bustamante Paco & Chastel Olivier, juillet 2022 — Possible interaction between exposure to environmental contaminants and nutritional stress in promoting disease occurrence in seabirds from French Guiana: a review. Reg Environ Change vol. 22, n° 2, p. 63
ISSN
1436-3798, 1436-378X
https://dx.doi.org/10.1007/s10113-022-01914-2
Deprouw Camille, Courties Alice, Fini Jean-Baptiste, Clerget-Froidevaux Marie-Stéphanie, Demeneix Barbara, Berenbaum Francis, Sellam Jérémie & Louati Karine, juillet 2022 — Pollutants: a candidate as a new risk factor for osteoarthritis-results from a systematic literature review. BACKGROUND : Considering non-classical environmental risk factors for osteoarthritis (OA), a systematic literature review … RMD Open vol. 8, n° 2, e001983
ISSN
2056-5933
https://dx.doi.org/10.1136/rmdopen-2021-001983
Aouci Rym, El Soudany Mey, Maakoul Zakaria, Fontaine Anastasia, Kurihara Hiroki, Levi Giovanni & Narboux-Nême Nicolas, mai 2022 — Dlx5/6 Expression Levels in Mouse GABAergic Neurons Regulate Adult Parvalbumin Neuronal Density and Anxiety/Compulsive Behaviours. Neuronal circuits integrating Parvalbumin-positive GABAergic inhibitory interneurons (PV) are essential for normal brain… Cells vol. 11, n° 11, p. 1739
ISSN
2073-4409
https://dx.doi.org/10.3390/cells11111739
Vancamp Pieter, Le Blay Karine, Butruille Lucile, Sébillot Anthony, Boelen Anita, Demeneix Barbara A. & Remaud Sylvie, mars 2022 — Developmental thyroid disruption permanently affects the neuroglial output in the murine subventricular zone. Neural stem cells (NSCs) in the adult brain are a source of neural cells for brain injury repair. We investigated whether… Stem Cell Reports vol. 17, n° 3, p. 459-474
ISSN
2213-6711
https://dx.doi.org/10.1016/j.stemcr.2022.01.002
Mullen Rachel D., Bellessort Brice, Levi Giovanni & Behringer Richard R., 2022 — Distal-less homeobox genes Dlx5/6 regulate Müllerian duct regression. Dlx5 and Dlx6 encode distal-less homeodomain transcription factors that are present in the genome as a linked pair at a single… Frontiers in Endocrinology vol. 13, , p. 916173
ISSN
1664-2392
https://dx.doi.org/10.3389/fendo.2022.916173
Luongo Cristina, Butruille Lucile, Sébillot Anthony, LeBlay Karine, Schwaninger Markus, Heuer Heike, Demeneix Barbara A. & Remaud Sylvie, mars 2021 — Absence of Both Thyroid Hormone Transporters MCT8 and OATP1C1 Impairs Neural Stem Cell Fate in the Adult Mouse Subventricular Zone. Adult neural stem cell (NSC) generation in vertebrate brains requires thyroid hormones (THs). How THs enter the NSC population… Stem Cell Reports vol. 16, n° 2, p. 337-353
ISSN
2213-6711
https://dx.doi.org/10.1016/j.stemcr.2020.12.009
Vancamp Pieter, Spirhanzlova Petra, Sébillot Anthony, Butruille Lucile, Gothié Jean-David, Le Mével Sébastien, Leemans Michelle, Wejaphikul Karn, Meima Marcel, Mughal Bilal B., Roques Pierre, Remaud Sylvie, Fini Jean-Baptiste & Demeneix Barbara A., 2021 — The pyriproxyfen metabolite, 4’-OH-PPF, disrupts thyroid hormone signaling in neural stem cells, modifying neurodevelopmental genes affected by ZIKA virus infection. North-Eastern Brazil saw intensive application of the insecticide pyriproxyfen (PPF) during the microcephaly outbreak caused… Environ Pollut. vol. 285, , p. 117654
ISSN
1873-6424
https://dx.doi.org/10.1016/j.envpol.2021.117654
Messina Simone, Edwards David Paul, Van Houtte Natalie, Tomassi Suzanne, Benedick Suzan, Eens Marcel & Costantini David, 2021 — Impacts of selective logging on haemosporidian infection and physiological correlates in tropical birds. Tropical forest degradation affects host-parasite interactions, determining the probability of animals acquiring an infection… Int J Parasitol. , , S0020–7519(21)00259–9
ISSN
1879-0135
https://dx.doi.org/10.1016/j.ijpara.2021.07.003
Cheron Marion, Costantini David, Angelier Frédéric, Ribout Cécile & Brischoux François, 2021 — Aminomethylphosphonic acid (AMPA) alters oxidative status during embryonic development in an amphibian species. Glyphosate’s primary metabolite (aminomethylphosphonic acid, AMPA) is known to alter embryonic development at environmentally… Chemosphere vol. 287, , p. 131882
ISSN
1879-1298
https://dx.doi.org/10.1016/j.chemosphere.2021.131882
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  • Gladys ALFAMA
  • Rym AOUCI
  • Anne BACHELOT
  • Lou BELZ
  • Lucile BUTRUILLE
  • Lamis CHAMAS
  • Marie-Stéphanie CLERGET-FROIDEVAUX
  • Laurent COEN
  • David COSTANTINI
  • Camille DE LOMBARES
  • Barbara DEMENEIX
  • Evelyne DUVERNOIS-BERTHET
  • Jean-Baptiste FINI
  • Anastasia FONTAINE
  • Fabrice GIRARDOT
  • Anni HERRANEN
  • Eglantine HEUDE
  • Karine LE BLAY
  • Sébastien LE MEVEL
  • Giovanni LEVI
  • Nicolas NARBOUX-NÊME
  • Sylvie REMAUD
  • Laurent SACHS
  • Manrico SEBASTIANO
  • Anthony SEBILLOT
  • Isabelle SEUGNET
  • Victor VALCARCEL-HERNANDEZ
  • Pieter VANCAMP

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