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PhyMA is a laboratory under the dual supervision of the CNRS (INEE) and the National Museum of Natural History.
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Physiologie moléculaire et adaptation
UMR 7221

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Pesce Elise, Benitez-Gonzalez Jessica, Tindall Andrew J., Lemkine Gregory F., Robin-Duchesne Barbara, Sachs Laurent M. & Pasquier Et David Du, September 2024 — Testing the sensitivity of the medaka Transgenic Eleuthero-embryonic THYroid-Specific assay (TETHYS) to different mechanisms of action. There are many concerns about the impacts of Endocrine-Disrupting Chemicals on both wildlife and human populations. A plethora… vol. 276, , p. 107081
ISSN
1879-1514
https://dx.doi.org/10.1016/j.aquatox.2024.107081
Chevalier Nicolas, Guillou Pauline, Viguié Catherine, Fini Jean-Baptiste, Sachs Laurent M., Michel-Caillet Cécile & Mhaouty-Kodja Sakina, June 2024 — Lithium and endocrine disruption: A concern for human health?. Lithium is a key medication for the treatment of psychiatric disorders and is also used in various industrial applications … Environment International , , p. 108861
ISSN
1873-6750
https://dx.doi.org/10.1016/j.envint.2024.108861
Tribondeau Alicia, Du Pasquier David, Benchouaia Médine, Blugeon Corinne, Buisine Nicolas & Sachs Laurent M., March 2024 — Overlapping action of T3 and T4 during Xenopus laevis development. Thyroid hormones are involved in many biological processes such as neurogenesis, metabolism, and development. However,… Frontiers in Endocrinology vol. 15, , p. 1360188
ISSN
1664-2392
https://dx.doi.org/10.3389/fendo.2024.1360188
Bredeson Jessen V., Mudd Austin B., Medina-Ruiz Sofia, Mitros Therese, Smith Owen Kabnick, Miller Kelly E., Lyons Jessica B., Batra Sanjit S., Park Joseph, Berkoff Kodiak C., Plott Christopher, Grimwood Jane, Schmutz Jeremy, Aguirre-Figueroa Guadalupe, Khokha Mustafa K. et al., January 2024 — Conserved chromatin and repetitive patterns reveal slow genome evolution in frogs. Frogs are an ecologically diverse and phylogenetically ancient group of anuran amphibians that include important vertebrate… Nat. Commun. vol. 15, n° 1, p. 579
ISSN
2041-1723
https://dx.doi.org/10.1038/s41467-023-43012-9
Pesce Elise, Garde Marion, Rigolet Muriel, Tindall Andrew J., Lemkine Gregory F., Baumann Lisa A., Sachs Laurent M. & Du Pasquier David, December 2023 — A Novel Transgenic Model to Study Thyroid Axis Activity in Early Life Stage Medaka. Identifying endocrine disrupting chemicals in order to limit their usage is a priority and required according to the European… Environ. Sci. Technol. , ,
ISSN
1520-5851
https://dx.doi.org/10.1021/acs.est.3c05515
Lazcano I., Olvera A., Pech-Pool S. M., Sachs L., Buisine N. & Orozco A., 2023 — Differential effects of 3,5-T2 and T3 on the gill regeneration and metamorphosis of the Ambystoma mexicanum (axolotl). Thyroid hormones (THs) regulate tissue remodeling processes during early- and post-embryonic stages in vertebrates. The Mexican… Front Endocrinol (Lausanne) vol. 14, , p. 1208182
ISSN
1664-2392
https://dx.doi.org/10.3389/fendo.2023.1208182
Rigolet Muriel, Buisine Nicolas, Scharwatt Marylou, Duvernois-Berthet Evelyne, Buchholz Daniel R. & Sachs Laurent M., November 2022 — Crosstalk between Thyroid Hormone and Corticosteroid Signaling Targets Cell Proliferation in Xenopus tropicalis Tadpole Liver. Thyroid hormones (TH) and glucocorticoids (GC) are involved in numerous developmental and physiological processes. The effects… Frontiers in Genetics vol. 23, n° 22, p. 13715
ISSN
1422-0067
https://dx.doi.org/10.3390/ijms232213715
Tribondeau Alicia, Sachs Laurent M. & Buisine Nicolas, October 2022 — Tetrabromobisphenol A effects on differentiating mouse embryonic stem cells reveals unexpected impact on immune system. Tetrabromobisphenol A (TBBPA) is a potent flame retardant used in numerous appliances and a major pollutant in households and… International Journal of Molecular Sciences vol. 13, , p. 996826
ISSN
1664-8021
https://dx.doi.org/10.3389/fgene.2022.996826
Paul Bidisha, Sterner Zachary R., Buchholz Daniel R., Shi Yun-Bo & Sachs Laurent M., May 2022 — Thyroid and Corticosteroid Signaling in Amphibian Metamorphosis. In multicellular organisms, development is based in part on the integration of communication systems. Two neuroendocrine axes,… Cells vol. 11, n° 10, p. 1595
ISSN
2073-4409
https://dx.doi.org/10.3390/cells11101595
Viengchareun Say, Pussard Eric, Castanet Mireille, Sachs Laurent M., Vu Thi An, Boileau Pascal, Lombès Marc & Martinerie Laetitia, June 2021 — The invention of aldosterone, how the past resurfaces in pediatric endocrinology. Sodium and water homeostasis are drastically modified at birth, in mammals, by the transition from aquatic life to terrestrial… Mol Cell Endocrinol , , p. 111375
ISSN
1872-8057
https://dx.doi.org/10.1016/j.mce.2021.111375
Tribondeau Alicia, Sachs Laurent M. & Buisine Nicolas, June 2021 — Are paedomorphs actual larvae?. Amphibians display very diverse life cycles and development can be direct, where it occurs in ovo and a juvenile hatches… Dev Dyn vol. 250, n° 6, p. 779-787
ISSN
1097-0177
https://dx.doi.org/10.1002/dvdy.304
Dufour Sylvie & Sachs Laurent M., March 2021 — The Chicken and Egg Situation of Thyroid Hormone and Glucocorticoid Signaling during Postembryonic Development. Endocrinology vol. 162, n° 3, bqaa243
ISSN
1945-7170
https://dx.doi.org/10.1210/endocr/bqaa243
Buisine Nicolas, Grimaldi Alexis, Jonchere Vincent, Rigolet Muriel, Blugeon Corinne, Hamroune Juliette & Sachs Laurent M, 2021 — Transcriptome and Methylome Analysis Reveal Complex Cross-Talks between Thyroid Hormone and Glucocorticoid Signaling at Xenopus Metamorphosis. Background: Most work in endocrinology focus on the action of a single hormone, and very little on the cross-talks between two… Cells vol. 10, n° 9, p. 2375
ISSN
2073-4409
https://dx.doi.org/10.3390/cells10092375
Rousseau Karine, Dufour Sylvie & Sachs Laurent M., 2021 — Interdependence of Thyroid and Corticosteroid Signaling in Vertebrate Developmental Transitions. Post-embryonic acute developmental processes mainly allow the transition from one life stage in a specific ecological niche to… Front. Ecol. Evol. vol. 9, , p. 735487
ISSN
2296-701X
https://dx.doi.org/10.3389/fevo.2021.735487
Kyono Yasuhiro, Raj Samhitha, Sifuentes Christopher J., Buisine Nicolas, Sachs Laurent & Denver Robert J., March 2020 — DNA methylation dynamics underlie metamorphic gene regulation programs in Xenopus tadpole brain. Methylation of cytosine residues in DNA influences chromatin structure and gene transcription, and its regulation is crucial… Dev. Biol. , ,
ISSN
1095-564X
https://dx.doi.org/10.1016/j.ydbio.2020.03.013
Holbech Henrik, Matthiessen Peter, Hansen Martin, Schüürmann Gerrit, Knapen Dries, Reuver Marieke, Flamant Frédéric, Sachs Laurent, Kloas Werner, Hilscherova Klara, Leonard Marc, Arning Jürgen, Strauss Volker, Iguchi Taisen & Baumann Lisa, March 2020 — ERGO : Breaking Down the Wall between Human Health and Environmental Testing of Endocrine Disrupters. ERGO (EndocRine Guideline Optimization) is the acronym of a European Union-funded research and innovation action, that aims to… Int J Mol Sci vol. 21, n° 8, p. 2954
ISSN
1422-0067
https://dx.doi.org/10.3390/ijms21082954
Sachs Laurent M. & Buchholz Daniel R., 2019 — Insufficiency of Thyroid Hormone in Frog Metamorphosis and the Role of Glucocorticoids. Front Endocrinol (Lausanne) vol. 10, , p. 287
ISSN
1664-2392
https://dx.doi.org/10.3389/fendo.2019.00287
Sachs Laurent M. & Campinho Marco A., 2019 — Editorial: The Role of Thyroid Hormones in Vertebrate Development. Front Endocrinol (Lausanne) vol. 10, , p. 863
ISSN
1664-2392
https://dx.doi.org/10.3389/fendo.2019.00863
Kerdivel Gwenneg, Blugeon Corinne, Fund Cédric, Rigolet Muriel, Sachs Laurent M. & Buisine Nicolas, 2019 — Opposite T3 Response of ACTG1-FOS Subnetwork Differentiate Tailfin Fate in Xenopus Tadpole and Post-hatching Axolotl. Front Endocrinol (Lausanne) vol. 10, , p. 194
ISSN
1664-2392
https://dx.doi.org/10.3389/fendo.2019.00194
Buisine Nicolas, Ruan Xiaoan, Ruan Yijun & Sachs Laurent M., August 2018 — Chromatin Interaction Analysis Using Paired-End-Tag (ChIA-PET) Sequencing in Tadpole Tissues. Cold Spring Harb Protoc vol. 2018, n° 8, pdb.prot104620
ISSN
1559-6095
https://dx.doi.org/10.1101/pdb.prot104620
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