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PhyMA is a laboratory under the dual supervision of the CNRS (INEE) and the National Museum of Natural History.
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Physiologie moléculaire et adaptation
UMR 7221

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Tribondeau Alicia, Du Pasquier David, Benchouaia Médine, Blugeon Corinne, Buisine Nicolas & Sachs Laurent M., March 2024 — Overlapping action of T3 and T4 during Xenopus laevis development. Thyroid hormones are involved in many biological processes such as neurogenesis, metabolism, and development. However,… Frontiers in Endocrinology vol. 15, , p. 1360188
ISSN
1664-2392
https://dx.doi.org/10.3389/fendo.2024.1360188
Bredeson Jessen V., Mudd Austin B., Medina-Ruiz Sofia, Mitros Therese, Smith Owen Kabnick, Miller Kelly E., Lyons Jessica B., Batra Sanjit S., Park Joseph, Berkoff Kodiak C., Plott Christopher, Grimwood Jane, Schmutz Jeremy, Aguirre-Figueroa Guadalupe, Khokha Mustafa K. et al., January 2024 — Conserved chromatin and repetitive patterns reveal slow genome evolution in frogs. Frogs are an ecologically diverse and phylogenetically ancient group of anuran amphibians that include important vertebrate… Nat. Commun. vol. 15, n° 1, p. 579
ISSN
2041-1723
https://dx.doi.org/10.1038/s41467-023-43012-9
Lazcano I., Olvera A., Pech-Pool S. M., Sachs L., Buisine N. & Orozco A., 2023 — Differential effects of 3,5-T2 and T3 on the gill regeneration and metamorphosis of the Ambystoma mexicanum (axolotl). Thyroid hormones (THs) regulate tissue remodeling processes during early- and post-embryonic stages in vertebrates. The Mexican… Front Endocrinol (Lausanne) vol. 14, , p. 1208182
ISSN
1664-2392
https://dx.doi.org/10.3389/fendo.2023.1208182
Rigolet Muriel, Buisine Nicolas, Scharwatt Marylou, Duvernois-Berthet Evelyne, Buchholz Daniel R. & Sachs Laurent M., November 2022 — Crosstalk between Thyroid Hormone and Corticosteroid Signaling Targets Cell Proliferation in Xenopus tropicalis Tadpole Liver. Thyroid hormones (TH) and glucocorticoids (GC) are involved in numerous developmental and physiological processes. The effects… Frontiers in Genetics vol. 23, n° 22, p. 13715
ISSN
1422-0067
https://dx.doi.org/10.3390/ijms232213715
Tribondeau Alicia, Sachs Laurent M. & Buisine Nicolas, October 2022 — Tetrabromobisphenol A effects on differentiating mouse embryonic stem cells reveals unexpected impact on immune system. Tetrabromobisphenol A (TBBPA) is a potent flame retardant used in numerous appliances and a major pollutant in households and… International Journal of Molecular Sciences vol. 13, , p. 996826
ISSN
1664-8021
https://dx.doi.org/10.3389/fgene.2022.996826
Tribondeau Alicia, Sachs Laurent M. & Buisine Nicolas, June 2021 — Are paedomorphs actual larvae?. Amphibians display very diverse life cycles and development can be direct, where it occurs in ovo and a juvenile hatches… Dev Dyn vol. 250, n° 6, p. 779-787
ISSN
1097-0177
https://dx.doi.org/10.1002/dvdy.304
Buisine Nicolas, Grimaldi Alexis, Jonchere Vincent, Rigolet Muriel, Blugeon Corinne, Hamroune Juliette & Sachs Laurent M, 2021 — Transcriptome and Methylome Analysis Reveal Complex Cross-Talks between Thyroid Hormone and Glucocorticoid Signaling at Xenopus Metamorphosis. Background: Most work in endocrinology focus on the action of a single hormone, and very little on the cross-talks between two… Cells vol. 10, n° 9, p. 2375
ISSN
2073-4409
https://dx.doi.org/10.3390/cells10092375
Kyono Yasuhiro, Raj Samhitha, Sifuentes Christopher J., Buisine Nicolas, Sachs Laurent & Denver Robert J., March 2020 — DNA methylation dynamics underlie metamorphic gene regulation programs in Xenopus tadpole brain. Methylation of cytosine residues in DNA influences chromatin structure and gene transcription, and its regulation is crucial… Dev. Biol. , ,
ISSN
1095-564X
https://dx.doi.org/10.1016/j.ydbio.2020.03.013
Kerdivel Gwenneg, Blugeon Corinne, Fund Cédric, Rigolet Muriel, Sachs Laurent M. & Buisine Nicolas, 2019 — Opposite T3 Response of ACTG1-FOS Subnetwork Differentiate Tailfin Fate in Xenopus Tadpole and Post-hatching Axolotl. Front Endocrinol (Lausanne) vol. 10, , p. 194
ISSN
1664-2392
https://dx.doi.org/10.3389/fendo.2019.00194
Buisine Nicolas, Ruan Xiaoan, Ruan Yijun & Sachs Laurent M., August 2018 — Chromatin Interaction Analysis Using Paired-End-Tag (ChIA-PET) Sequencing in Tadpole Tissues. Cold Spring Harb Protoc vol. 2018, n° 8, pdb.prot104620
ISSN
1559-6095
https://dx.doi.org/10.1101/pdb.prot104620
Buisine Nicolas, Ruan Xiaoan, Ruan Yijun & Sachs Laurent M., August 2018 — Chromatin Immunoprecipitation for Chromatin Interaction Analysis Using Paired-End-Tag (ChIA-PET) Sequencing in Tadpole Tissues. Cold Spring Harb Protoc vol. 2018, n° 8, pdb.prot097725
ISSN
1559-6095
https://dx.doi.org/10.1101/pdb.prot097725
Buisine Nicolas, Kerdivel Gwenneg & Sachs Laurent M., 2018 — De Novo Transcriptomic Approach to Study Thyroid Hormone Receptor Action in Non-mammalian Models. Methods Mol. Biol. vol. 1801, , p. 265-285
ISSN
1940-6029
https://dx.doi.org/10.1007/978-1-4939-7902-8_21
Schneider Katelin A., Shewade Leena H., Buisine Nicolas, Sachs Laurent M. & Buchholz Daniel R., 2018 — A novel stress hormone response gene in tadpoles of Xenopus tropicalis. Gen. Comp. Endocrinol. vol. 260, , p. 107-114
ISSN
1095-6840
https://dx.doi.org/10.1016/j.ygcen.2018.01.006
Olvera A., Martyniuk C. J., Buisine N., Jiménez-Jacinto V., Sanchez-Flores A., Sachs L. M. & Orozco A., November 2017 — Differential transcriptome regulation by 3,5-T2 and 3’,3,5-T3 in brain and liver uncovers novel roles for thyroid hormones in tilapia. Sci Rep vol. 7, n° 1, p. 15043
ISSN
2045-2322
https://dx.doi.org/10.1038/s41598-017-14913-9
Bagamasbad Pia D., Bonett Ronald M., Sachs Laurent, Buisine Nicolas, Raj Samhitha, Knoedler Joseph R., Kyono Yasuhiro, Ruan Yijun, Ruan Xiaoan & Denver Robert J., June 2015 — Deciphering the regulatory logic of an ancient, ultraconserved nuclear receptor enhancer module. Mol. Endocrinol. vol. 29, n° 6, p. 856-872
ISSN
1944-9917
https://dx.doi.org/10.1210/me.2014-1349
Buisine Nicolas, Ruan Xiaoan, Bilesimo Patrice, Grimaldi Alexis, Alfama Gladys, Ariyaratne Pramila, Mulawadi Fabianus, Chen Jieqi, Sung Wing-Kin, Liu Edison T., Demeneix Barbara A., Ruan Yijun & Sachs Laurent M., 2015 — Xenopus tropicalis Genome Re-Scaffolding and Re-Annotation Reach the Resolution Required for In Vivo ChIA-PET Analysis. PLoS ONE vol. 10, n° 9, e0137526
ISSN
1932-6203
https://dx.doi.org/10.1371/journal.pone.0137526
Zambrano Alberto, García-Carpizo Verónica, Gallardo MaríaEsther, Villamuera Raquel, Gómez-Ferrería Maria Ana, Pascual Angel, Buisine Nicolas, Sachs Laurent M., Garesse Rafael & Aranda Ana, January 2014 — The thyroid hormone receptor β induces DNA damage and premature senescence. J. Cell Biol. vol. 204, n° 1, p. 129-146
ISSN
1540-8140
https://dx.doi.org/10.1083/jcb.201305084
Aldea Daniel, Hanna Patricia, Munoz David, Espinoza Javier, Torrejon Marcela, Sachs Laurent, Buisine Nicolas, Oulion Silvan, Escriva Hector & Marcellini Sylvain, September 2013 — Evolution of the vertebrate bone matrix: an expression analysis of the network forming collagen paralogues in amphibian osteoblasts. J. Exp. Zool. B Mol. Dev. Evol. vol. 320, n° 6, p. 375-384
ISSN
1552-5015
https://dx.doi.org/10.1002/jez.b.22511
Grimaldi Alexis, Buisine Nicolas, Miller Thomas, Shi Yun-Bo & Sachs Laurent M., July 2013 — Mechanisms of thyroid hormone receptor action during development: lessons from amphibian studies. Biochim. Biophys. Acta vol. 1830, n° 7, p. 3882-3892
ISSN
0006-3002
https://dx.doi.org/10.1016/j.bbagen.2012.04.020
Grimaldi Alexis G., Buisine Nicolas, Bilesimo Patrice & Sachs Laurent M., 2013 — High-throughput sequencing will metamorphose the analysis of thyroid hormone receptor function during amphibian development. Curr. Top. Dev. Biol. vol. 103, , p. 277-303
ISSN
1557-8933
https://dx.doi.org/10.1016/B978-0-12-385979-2.00010-1
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