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Physiologie moléculaire et adaptation
UMR 7221

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Vom Saal Frederick S., Antoniou Michael, Belcher Scott M., Bergman Ake, Bhandari Ramji K., Birnbaum Linda S., Cohen Aly, Collins Terrence J., Demeneix Barbara, Fine Anne Marie, Flaws Jodi A., Gayrard Veronique, Goodson William H., Gore Andrea C., Heindel Jerrold J. et al., March 2024 — The Conflict between Regulatory Agencies over the 20,000-Fold Lowering of the Tolerable Daily Intake (TDI) for Bisphenol A (BPA) by the European Food Safety Authority (EFSA). BACKGROUND: The European Food Safety Authority (EFSA) recommended lowering their estimated tolerable daily intake (TDI) for… Environmental Health Perspectives vol. 132, n° 4, p. 45001
ISSN
1552-9924
https://dx.doi.org/10.1289/EHP13812
Rannaud-Bartaire Patricia, Demeneix Barbara A. & Fini Jean-Baptiste, December 2023 — Pressures of the urban environment on the endocrine system: Adverse effects and adaptation. With an increasing collective awareness of the rapid environmental changes, questions and theories regarding the adaptability… Mol. Cell. Endocrinol. , , p. 112125
ISSN
1872-8057
https://dx.doi.org/10.1016/j.mce.2023.112125
Butruille L., Jubin P., Martin E., Aigrot M. S., Lhomme M., Fini J. B., Demeneix B., Stankoff B., Lubetzki C., Zalc B. & Remaud S., September 2023 — Deleterious functional consequences of perfluoroalkyl substances accumulation into the myelin sheath. Exposure to persistent organic pollutants during the perinatal period is of particular concern because of the potential… vol. 180, , p. 108211
ISSN
1873-6750
https://dx.doi.org/10.1016/j.envint.2023.108211
Derakhshan Arash, Shu Huan, Broeren Maarten A. C., Kortenkamp Andreas, Lindh Christian H., Demeneix Barbara, Peeters Robin P., Bornehag Carl-Gustaf & Korevaar Tim I. M., July 2023 — Association of endocrine disrupting chemicals exposure with human chorionic gonadotropin concentrations in pregnancy. BACKGROUND: Human chorionic gonadotropin (hCG) is produced by the placenta and plays an essential role in the maintenance of… Environ Int vol. 178, , p. 108091
ISSN
1873-6750
https://dx.doi.org/10.1016/j.envint.2023.108091
Spirhanzlova Petra, Couderq Stephan, Le Mével Sébastian, Leemans Michelle, Krief Sabrina, Mughal Bilal B., Demeneix Barbara A. & Fini Jean-Baptiste, June 2023 — Short and long term effects of chlorpyrifos on thyroid hormone axis and brain development in Xenopus laevis. INTRODUCTION: The extensive use of the insecticide chlorpyrifos (CPF) throughout the world has brought increased scrutiny on… Neuroendocrinology vol. 113, n° 12, p. 1298-1311
ISSN
1423-0194
https://dx.doi.org/10.1159/000525719
Sapounidou Maria, Andersson Patrik L., Leemans Michelle, Fini Jean-Baptiste, Demeneix Barbara, Rüegg Joëlle, Bornehag Carl-Gustaf & Gennings Chris, March 2023 — From Cohort to Cohort: A Similar Mixture Approach (SMACH) to Evaluate Exposures to a Mixture Leading to Thyroid-Mediated Neurodevelopmental Effects Using NHANES Data. Prenatal exposure to a mixture (MIX N) of eight endocrine-disrupting chemicals has been associated with language delay in… Toxics vol. 11, n° 4, p. 331
ISSN
2305-6304
https://dx.doi.org/10.3390/toxics11040331
Butruille Lucile, Sébillot Anthony, Ávila Katia, Vancamp Pieter, Demeneix Barbara A., Pifferi Fabien & Remaud Sylvie, February 2023 — Increased oligodendrogenesis and myelination in the subventricular zone of aged mice and gray mouse lemurs. The adult rodent subventricular zone (SVZ) generates neural stem cells (NSCs) throughout life that migrate to the olfactory… Stem Cell Reports vol. 18, n° 2, p. 534-554
ISSN
2213-6711
https://dx.doi.org/10.1016/j.stemcr.2022.12.015
Leemans Michelle, Spirhanzlova Petra, Couderq Stephan, LeMével Sébastien, Grimaldi Alexis, Duvernois-Berthet Evelyne, Demeneix Barbara & Fini Jean-Baptiste, January 2023 — A Mixture of Chemicals Found in Human Amniotic Fluid Disrupts Brain Gene Expression and Behavior in Xenopus laevis. Thyroid hormones (TH) are essential for normal brain development, influencing neural cell differentiation, migration, and… Int J Mol Sci. vol. 24, n° 3, p. 2588
ISSN
1422-0067
https://dx.doi.org/10.3390/ijms24032588
Vancamp Pieter, Butruille Lucile, Herranen Anni, Boelen Anita, Fini Jean-Baptiste, Demeneix Barbara A. & Remaud Sylvie, January 2023 — Transient developmental exposure to low doses of bisphenol F negatively affects neurogliogenesis and olfactory behaviour in adult mice. Neural stem cells in the murine subventricular zone (SVZ) reactivate during postnatal development to generate neurons and glia… Environ Int . vol. 172, , p. 107770
ISSN
1873-6750
https://dx.doi.org/10.1016/j.envint.2023.107770
Derakhshan Arash, Kortenkamp Andreas, Shu Huan, Broeren Maarten A. C., Lindh Christian H., Peeters Robin P., Bornehag Carl-Gustaf, Demeneix Barbara & Korevaar Tim I. M., September 2022 — Association of per- and polyfluoroalkyl substances with thyroid homeostasis during pregnancy in the SELMA study. OBJECTIVES : To investigate the association of exposure to per- and polyfluoroalkyl substances (PFAS) during early… Environ Int . vol. 167, , p. 107420
ISSN
1873-6750
https://dx.doi.org/10.1016/j.envint.2022.107420
Deprouw Camille, Courties Alice, Fini Jean-Baptiste, Clerget-Froidevaux Marie-Stéphanie, Demeneix Barbara, Berenbaum Francis, Sellam Jérémie & Louati Karine, June 2022 — Pollutants: a candidate as a new risk factor for osteoarthritis-results from a systematic literature review. BACKGROUND : Considering non-classical environmental risk factors for osteoarthritis (OA), a systematic literature review … RMD Open vol. 8, n° 2, e001983
ISSN
2056-5933
https://dx.doi.org/10.1136/rmdopen-2021-001983
Vancamp Pieter, Le Blay Karine, Butruille Lucile, Sébillot Anthony, Boelen Anita, Demeneix Barbara A. & Remaud Sylvie, March 2022 — Developmental thyroid disruption permanently affects the neuroglial output in the murine subventricular zone. Neural stem cells (NSCs) in the adult brain are a source of neural cells for brain injury repair. We investigated whether… Stem Cell Reports vol. 17, n° 3, p. 459-474
ISSN
2213-6711
https://dx.doi.org/10.1016/j.stemcr.2022.01.002
Caporale Nicolò, Leemans Michelle, Birgersson Lina, Germain Pierre-Luc, Cheroni Cristina, Borbély Gábor, Engdahl Elin, Lindh Christian, Bressan Raul Bardini, Cavallo Francesca, Chorev Nadav Even, D’Agostino Giuseppe Alessandro, Pollard Steven M., Rigoli Marco Tullio, Tenderini Erika et al., February 2022 — From cohorts to molecules: Adverse impacts of endocrine disrupting mixtures. Convergent evidence associates exposure to endocrine disrupting chemicals (EDCs) with major human diseases, even at regulation… Science vol. 375, n° 6582, eabe8244
ISSN
1095-9203
https://dx.doi.org/10.1126/science.abe8244
Derakhshan Arash, Shu Huan, Broeren Maarten A. C., Lindh Christian H., Peeters Robin P., Kortenkamp Andreas, Demeneix Barbara, Bornehag Carl-Gustaf & Korevaar Tim I. M., December 2021 — Association of phthalate exposure with thyroid function during pregnancy. BACKGROUND : The extent of thyroid disruptive effects of phthalates during pregnancy remains unclear. AIM: To investigate the… Environ Int. vol. 157, , p. 106795
ISSN
1873-6750
https://dx.doi.org/10.1016/j.envint.2021.106795
Luongo Cristina, Butruille Lucile, Sébillot Anthony, LeBlay Karine, Schwaninger Markus, Heuer Heike, Demeneix Barbara A. & Remaud Sylvie, February 2021 — Absence of Both Thyroid Hormone Transporters MCT8 and OATP1C1 Impairs Neural Stem Cell Fate in the Adult Mouse Subventricular Zone. Adult neural stem cell (NSC) generation in vertebrate brains requires thyroid hormones (THs). How THs enter the NSC population… Stem Cell Reports vol. 16, n° 2, p. 337-353
ISSN
2213-6711
https://dx.doi.org/10.1016/j.stemcr.2020.12.009
Vancamp Pieter, Spirhanzlova Petra, Sébillot Anthony, Butruille Lucile, Gothié Jean-David, Le Mével Sébastien, Leemans Michelle, Wejaphikul Karn, Meima Marcel, Mughal Bilal B., Roques Pierre, Remaud Sylvie, Fini Jean-Baptiste & Demeneix Barbara A., 2021 — The pyriproxyfen metabolite, 4’-OH-PPF, disrupts thyroid hormone signaling in neural stem cells, modifying neurodevelopmental genes affected by ZIKA virus infection. North-Eastern Brazil saw intensive application of the insecticide pyriproxyfen (PPF) during the microcephaly outbreak caused… Environ Pollut. vol. 285, , p. 117654
ISSN
1873-6424
https://dx.doi.org/10.1016/j.envpol.2021.117654
Delfosse Vanessa, Huet Tiphaine, Harrus Deborah, Granell Meritxell, Bourguet Maxime, Gardia-Parège Caroline, Chiavarina Barbara, Grimaldi Marina, Le Mével Sébastien, Blanc Pauline, Huang David, Gruszczyk Jakub, Demeneix Barbara, Cianférani Sarah, Fini Jean-Baptiste et al., 2021 — Mechanistic insights into the synergistic activation of the RXR-PXR heterodimer by endocrine disruptor mixtures. Humans are chronically exposed to mixtures of xenobiotics referred to as endocrine-disrupting chemicals (EDCs). A vast body of… Proc Natl Acad Sci USA vol. 118, n° 1, e2020551118
ISSN
1091-6490
https://dx.doi.org/10.1073/pnas.2020551118
Butruille Lucile, Vancamp Pieter, Demeneix Barbara A. & Remaud Sylvie, 2021 — Thyroid hormone regulation of adult neural stem cell fate: A comparative analysis between rodents and primates. Thyroid hormone (TH) signaling, a highly conserved pathway across vertebrates, is crucial for brain development and function… Vitam Horm . vol. 116, , p. 133-192
ISSN
0083-6729
https://dx.doi.org/10.1016/bs.vh.2021.02.009
Demeneix Barbara, Vandenberg Laura N., Ivell Richard & Zoeller R. Thomas, October 2020 — Thresholds and Endocrine Disruptors: An Endocrine Society Policy Perspective. The concept of a threshold of adversity in toxicology is neither provable nor disprovable. As such, it is not a scientific… J Endocr Soc . vol. 4, n° 10, bvaa085
ISSN
2472-1972
https://dx.doi.org/10.1210/jendso/bvaa085
Lupu Diana, Andersson Patrik, Bornehag Carl-Gustaf, Demeneix Barbara, Fritsche Ellen, Gennings Chris, Lichtensteiger Walter, Leist Marcel, Leonards Pim E. G., Ponsonby Anne-Louise, Scholze Martin, Testa Giuseppe, Tresguerres Jesus A. F., Westerink Remco H. S., Zalc Bernard et al., June 2020 — The ENDpoiNTs Project: Novel Testing Strategies for Endocrine Disruptors Linked to Developmental Neurotoxicity. Ubiquitous exposure to endocrine-disrupting chemicals (EDCs) has caused serious concerns about the ability of these chemicals… Int J Mol Sci vol. 21, n° 11, p. 3978
ISSN
1422-0067
https://dx.doi.org/10.3390/ijms21113978
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