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PhyMA is a laboratory under the dual supervision of the CNRS (INEE) and the National Museum of Natural History.
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Physiologie moléculaire et adaptation
UMR 7221

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Antoine-Lorquin Aymeric, Arensburger Peter, Arnaoty Ahmed, Asgari Sassan, Batailler Martine, Beauclair Linda, Belleannée Catherine, Buisine Nicolas, Coustham Vincent, Guyetant Serge, Helou Laura, Lecomte Thierry, Pitard Bruno, Stévant Isabelle & Bigot Yves, May 2021 — Two repeated motifs enriched within some enhancers and origins of replication are bound by SETMAR isoforms in human colon cells. Setmar is a gene specific to simian genomes. The function(s) of its isoforms are poorly understood and their existence in… Genomics vol. 113, n° 3, p. 1589-1604
ISSN
1089-8646
https://dx.doi.org/10.1016/j.ygeno.2021.03.032
Helou Laura, Beauclair Linda, Dardente Hugues, Arensburger Peter, Buisine Nicolas, Jaszczyszyn Yan, Guillou Florian, Lecomte Thierry, Kentsis Alex & Bigot Yves, April 2021 — The C-terminal Domain of piggyBac Transposase Is Not Required for DNA Transposition. PiggyBac(PB)-like elements (pble) are members of a eukaryotic DNA transposon family. This family is of interest to evolutionary… J Mol Biol vol. 433, n° 7, p. 166805
ISSN
1089-8638
https://dx.doi.org/10.1016/j.jmb.2020.166805
Buisine Nicolas, Grimaldi Alexis, Jonchere Vincent, Rigolet Muriel, Blugeon Corinne, Hamroune Juliette & Sachs Laurent M, 2021 — Transcriptome and Methylome Analysis Reveal Complex Cross-Talks between Thyroid Hormone and Glucocorticoid Signaling at Xenopus Metamorphosis. Background: Most work in endocrinology focus on the action of a single hormone, and very little on the cross-talks between two… Cells vol. 10, n° 9, p. 2375
ISSN
2073-4409
https://dx.doi.org/10.3390/cells10092375
Rousseau Karine, Dufour Sylvie & Sachs Laurent M., 2021 — Interdependence of Thyroid and Corticosteroid Signaling in Vertebrate Developmental Transitions. Post-embryonic acute developmental processes mainly allow the transition from one life stage in a specific ecological niche to… Front. Ecol. Evol. vol. 9, , p. 735487
ISSN
2296-701X
https://dx.doi.org/10.3389/fevo.2021.735487
Nguyen Duy, Fayol Olivier, Buisine Nicolas, Lecorre Pierrette & Uguen Patricia, 2016 — Functional Interaction between HEXIM and Hedgehog Signaling during Drosophila Wing Development. Studying the dynamic of gene regulatory networks is essential in order to understand the specific signals and factors that… PLoS One vol. 11, n° 5, e0155438
ISSN
1932-6203
https://dx.doi.org/10.1371/journal.pone.0155438
Messina Simone, Costantini David & Eens Marcel, Sci Total Environ March 2023 — Impacts of rising temperatures and water acidification on the oxidative status and immune system of aquatic ectothermic vertebrates: A meta-analysis. Species persistence in the Anthropocene is dramatically threatened by global climate change. Large emissions of carbon dioxide… vol. 868, , p. 161580
ISSN
1879-1026
https://dx.doi.org/10.1016/j.scitotenv.2023.161580
Pasquier Elodie, Viguié Catherine, Fini Jean-Baptiste, Mhaouty-Kodja Sakina & Michel-Caillet Cécile, March 2023 — Limits of the regulatory evaluation of resorcinol as a thyroid disruptor: When limited experimental data challenge established effects in humans. Severe hypothyroidism has been reported in humans during resorcinol therapeutic use. However, available data highlight… Environ Res vol. 222, , p. 115330
ISSN
1096-0953
https://dx.doi.org/10.1016/j.envres.2023.115330
Favreau Charly, Tribondeau Alicia, Marugan Marie, Guyot François, Alpha-Bazin Beatrice, Marie Arul, Puppo Remy, Dufour Thierry, Huguet Arnaud, Zirah Séverine & Kish Adrienne, 2022 — Molecular acclimation of Halobacterium salinarum to halite brine inclusions. Halophilic microorganisms have long been known to survive within the brine inclusions of salt crystals, as evidenced by the… Front Microbiol . vol. 13, , p. 1075274
ISSN
1664-302X
https://dx.doi.org/10.3389/fmicb.2022.1075274
Vancamp Pieter, Spirhanzlova Petra, Sébillot Anthony, Butruille Lucile, Gothié Jean-David, Le Mével Sébastien, Leemans Michelle, Wejaphikul Karn, Meima Marcel, Mughal Bilal B., Roques Pierre, Remaud Sylvie, Fini Jean-Baptiste & Demeneix Barbara A., 2021 — The pyriproxyfen metabolite, 4’-OH-PPF, disrupts thyroid hormone signaling in neural stem cells, modifying neurodevelopmental genes affected by ZIKA virus infection. North-Eastern Brazil saw intensive application of the insecticide pyriproxyfen (PPF) during the microcephaly outbreak caused… Environ Pollut. vol. 285, , p. 117654
ISSN
1873-6424
https://dx.doi.org/10.1016/j.envpol.2021.117654
Messina Simone, Edwards David Paul, Van Houtte Natalie, Tomassi Suzanne, Benedick Suzan, Eens Marcel & Costantini David, 2021 — Impacts of selective logging on haemosporidian infection and physiological correlates in tropical birds. Tropical forest degradation affects host-parasite interactions, determining the probability of animals acquiring an infection… Int J Parasitol. , , S0020–7519(21)00259–9
ISSN
1879-0135
https://dx.doi.org/10.1016/j.ijpara.2021.07.003
Toussaint-Lardé Isabelle, Louppe Vivien, Sanchez-Garrido Frida, Taillades Morgane, Amine Ryadh, Mandica Mark, Heude Eglantine, Herrel Anthony & Fabre Anne-Claire, July 2025 — The impact of size and ontogeny on suction feeding kinematics in the axolotl (Ambystoma mexicanum). Size impacts all aspects of life in animals. Not only does it impact metabolism and physiology, it also affects movements,… Biology Open vol. 14, n° 7, bio061860
ISSN
2046-6390
https://dx.doi.org/10.1242/bio.061860
Goutte Aurélie, Martin Nicolas, Alliot Fabrice, Angelier Frédéric, Blanchouin Arnaud, Costantini David, Lesimple Maxime, Ribout Cécile, Traoré Sira, Villalta Rémi & Blanchoud Hélène, December 2024 — From cells to recapture rates: responses and recovery of a wild fish after an experimental exposure to a widely used herbicide. Environmental Science and Pollution Research , ,
ISSN
1614-7499
https://dx.doi.org/10.1007/s11356-024-35837-8
Dufour Sylvie, Sachs Laurent, Martin Patrick & Rousseau Karine, 2025 — [Metamorphoses in fishes and their endocrine regulations]. The most emblematic metamorphoses in the animal kingdom remain those of the caterpillar into a butterfly and the tadpole into a… Biologie Aujourd'hui vol. 219, n° 1, p. 37-50
ISSN
2105-0686
https://dx.doi.org/10.1051/jbio/2025002
Nashed Salomé, Louis Emeric, Buisine Nicolas & Sachs Laurent M., May 2026 — Molecular and genetic studies on the signaling and the regulation of amphibian metamorphosis by thyroid hormone, the contribution of Jamshed Tata and Donald Brown. Post-embryonic development refers to the process by which embryonic development has been completed and the organism reaches… Developmental Biology vol. 533, , p. 181-188
ISSN
1095-564X
https://dx.doi.org/10.1016/j.ydbio.2026.02.013
Bichon Bérénice, Alfama Gladys, Gaillard Anne-Laure, Quan Feng B., Sourdaine Pascal & Tostivint Hervé, January 2026 — Characterization and expression of urotensin1 and urotensin2 genes in the caudal neurosecretory system of the small-spotted catshark Scyliorhinus canicula. The caudal neurosecretory system (CNSS) is a neuroendocrine complex unique to fish. In teleosts, the neuroendocrine neurons of… General and Comparative Endocrinology vol. 376, , p. 114866
ISSN
1095-6840
https://dx.doi.org/10.1016/j.ygcen.2025.114866
Bichon Bérénice, Alfama Gladys, Gaillard Anne-Laure, Tostivint Hervé & Pézeron Guillaume, September 2025 — Impact of acute environmental challenges on the expression of peptide hormone-encoding genes in the zebrafish caudal neurosecretory system. The caudal neurosecretory system (CNSS) is a neuroendocrine complex unique to fish, first described in 1955. Since then, it has… Comparative Biochemistry and Physiology. Part A, Molecular & Integrative Physiology vol. 307, , p. 111893
ISSN
1531-4332
https://dx.doi.org/10.1016/j.cbpa.2025.111893
Valcarcel-Hernandez V., Butruille L. & Remaud S., December 2025 — Effects of thyroid disruption on neural cells stem fate in the mouse brain. Thyroid hormones (THs), particularly T3 and T4, play crucial roles in neural development and maintenance by regulating neural… Presse Medicale vol. 54, n° 4, p. 104312
ISSN
2213-0276
https://dx.doi.org/10.1016/j.lpm.2025.104312
Ardenkjær-Skinnerup Jacob, Baert Yoni, Bajard Lola, Blum Jonathan, Brion François, Coppola Lucia, Fini Jean-Baptiste, Fritsche Ellen, Holbech Henrik, Hurem Selma, Jacobs Miriam Naomi, Johansson Hanna Katarina Lilith, Knapen Dries, Koch Katharina, Lyche Jan Ludvig et al., 2026 — New approach methodologies (NAMs) for improved developmental and reproductive toxicity (DART) assessment with focus on endocrine disruption - a PARC project. Endocrine disruptors (EDs) are implicated in adverse developmental and reproductive outcomes, yet their identification remains… Frontiers in Toxicology vol. 8, , p. 1736963
ISSN
2673-3080
https://dx.doi.org/10.3389/ftox.2026.1736963
Elagali Ahmed, Rüegg Joëlle, Caporale Nicolò, Testa Giuseppe, Sapounidou Maria, Fini Jean-Baptiste, Andersson Patrik L., Dunlop Sarah, Bornehag Carl-Gustaf & Gennings Chris, March 2026 — From correlation to causation: Integrating cohorts with experimental studies in mixture toxicology. Harmful chemical mixtures are pervasive in the environment, yet traditional epidemiological designs face major challenges in… Neurotoxicology vol. 113, , p. 103399
ISSN
1872-9711
https://dx.doi.org/10.1016/j.neuro.2026.103399
European Food Safety Authority (EFSA) and Baumann Lisa, Baynes Alice, Bennekou Susanne Hougaard, Crofton Kevin, Dang Zhichao, Degitz Sigmund, Fini Jean-Baptiste, Gilbert Mary, Holbech Henrik, Terron Andrea, Van Duursen Majorie, McVey Emily, Arena Maria, Kienzler Aude, Rizzuto Simone et al., December 2025 — The assessment for potential thyroid-mediated endocrine disruption in amphibians: Clarification on the use of new methods and on the interpretation of changes in thyroid histology. Amphibians (specifically Xenopus laevis) are used as the model species to assess potential endocrine-disrupting properties in… EFSA journal. European Food Safety Authority vol. 23, n° 12, e9815
ISSN
1831-4732
https://dx.doi.org/10.2903/j.efsa.2025.9815
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