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PhyMA is a laboratory under the dual supervision of the CNRS (INEE) and the National Museum of Natural History.
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Physiologie moléculaire et adaptation
UMR 7221

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Delfosse Vanessa, Huet Tiphaine, Harrus Deborah, Granell Meritxell, Bourguet Maxime, Gardia-Parège Caroline, Chiavarina Barbara, Grimaldi Marina, Le Mével Sébastien, Blanc Pauline, Huang David, Gruszczyk Jakub, Demeneix Barbara, Cianférani Sarah, Fini Jean-Baptiste et al., 2021 — Mechanistic insights into the synergistic activation of the RXR-PXR heterodimer by endocrine disruptor mixtures. Humans are chronically exposed to mixtures of xenobiotics referred to as endocrine-disrupting chemicals (EDCs). A vast body of… Proc Natl Acad Sci USA vol. 118, n° 1, e2020551118
ISSN
1091-6490
https://dx.doi.org/10.1073/pnas.2020551118
Usal Marie, Veyrenc Sylvie, Darracq-Ghitalla-Ciock Marie, Regnault Christophe, Sroda Sophie, Fini Jean-Baptiste, Canlet Cécile, Tremblay-Franco Marie, Raveton Muriel & Reynaud Stéphane, 2021 — Transgenerational metabolic disorders and reproduction defects induced by benzo[a]pyrene in Xenopus tropicalis. Metabolic disorders induced by endocrine disruptors (ED) may contribute to amphibian population declines but no… Environ Pollut vol. 269, , p. 116109
ISSN
1873-6424
https://dx.doi.org/10.1016/j.envpol.2020.116109
Sobrido-Cameán D., Yáñez-Guerra L. A., Deber A., Freire-Delgado M., Cacheiro-Vázquez R., Rodicio M. C., Tostivint H., Anadón R. & Barreiro-Iglesias A., February 2021 — Differential expression of somatostatin genes in the central nervous system of the sea lamprey. The identification of three somatostatin (SST) genes (SSTa, SSTb, and SSTc) in lampreys (Tostivint et al. Gen Comp Endocrinol… Brain Struct Funct , ,
ISSN
1863-2661
https://dx.doi.org/10.1007/s00429-021-02224-9
Viengchareun Say, Pussard Eric, Castanet Mireille, Sachs Laurent M., Vu Thi An, Boileau Pascal, Lombès Marc & Martinerie Laetitia, June 2021 — The invention of aldosterone, how the past resurfaces in pediatric endocrinology. Sodium and water homeostasis are drastically modified at birth, in mammals, by the transition from aquatic life to terrestrial… Mol Cell Endocrinol , , p. 111375
ISSN
1872-8057
https://dx.doi.org/10.1016/j.mce.2021.111375
Tribondeau Alicia, Sachs Laurent M. & Buisine Nicolas, June 2021 — Are paedomorphs actual larvae?. Amphibians display very diverse life cycles and development can be direct, where it occurs in ovo and a juvenile hatches… Dev Dyn vol. 250, n° 6, p. 779-787
ISSN
1097-0177
https://dx.doi.org/10.1002/dvdy.304
Cheron Marion, Costantini David, Angelier Frédéric, Ribout Cécile & Brischoux François, 2021 — Aminomethylphosphonic acid (AMPA) alters oxidative status during embryonic development in an amphibian species. Glyphosate’s primary metabolite (aminomethylphosphonic acid, AMPA) is known to alter embryonic development at environmentally… Chemosphere vol. 287, , p. 131882
ISSN
1879-1298
https://dx.doi.org/10.1016/j.chemosphere.2021.131882
Ohmer Michel E. B., Costantini David, Czirják Gábor Á, Downs Cynthia J., Ferguson Laura V., Flies Andy, Franklin Craig E., Kayigwe Ahab N., Knutie Sarah, Richards-Zawacki Corinne L. & Cramp Rebecca L., 2021 — Applied ecoimmunology: using immunological tools to improve conservation efforts in a changing world. Ecoimmunology is a rapidly developing field that explores how the environment shapes immune function, which in turn influences… Conserv Physiol. vol. 9, n° 1, coab074
ISSN
2051-1434
https://dx.doi.org/10.1093/conphys/coab074
Derakhshan Arash, Shu Huan, Broeren Maarten A. C., Lindh Christian H., Peeters Robin P., Kortenkamp Andreas, Demeneix Barbara, Bornehag Carl-Gustaf & Korevaar Tim I. M., December 2021 — Association of phthalate exposure with thyroid function during pregnancy. BACKGROUND : The extent of thyroid disruptive effects of phthalates during pregnancy remains unclear. AIM: To investigate the… Environ Int. vol. 157, , p. 106795
ISSN
1873-6750
https://dx.doi.org/10.1016/j.envint.2021.106795
Alejevski Faredin, Leemans Michelle, Gaillard Anne-Laure, Leistenschneider David, de Flori Céline, Bougerol Marion, LeMével Sébastien, Herrel Anthony, Fini Jean-Baptiste, Pézeron Guillaume & Tostivint Hervé, August 2021 — Conserved role of the urotensin II receptor 4 signalling pathway to control body straightness in a tetrapod. Urp1 and Urp2 are two neuropeptides of the urotensin II family identified in teleost fish and mainly expressed in… Open Biology vol. 11, n° 8, p. 210065
ISSN
2046-2441
https://dx.doi.org/10.1098/rsob.210065
Levi Giovanni, de Lombares Camille, Giuliani Cristina, Iannuzzi Vincenzo, Aouci Rym, Garagnani Paolo, Franceschi Claudio, Grimaud-Hervé Dominique & Narboux-Nême Nicolas, 2021 — DLX 5/6 GABAergic expression affects social vocalization: implications for human evolution. DLX 5 and DLX6 are two closely related transcription factors involved in brain development and in GABAergic differentiation… Mol. Biol. Evol. , , msab181
ISSN
1537-1719
https://dx.doi.org/10.1093/molbev/msab181
Costantini David, Masi Shelly, Rachid Lyna, Beltrame Marielle, Rohmer Mélanie & Krief Sabrina, 2021 — Mind the food: rapid changes in antioxidant content of diet affect oxidative status of chimpanzees. The link between dietary antioxidants and oxidative status has been studied extensively in humans. Surprisingly, comparative… Am J Physiol Regul Integr Comp Physiol vol. 320, n° 5, R728–R734
ISSN
1522-1490
https://dx.doi.org/10.1152/ajpregu.00003.2021
Marasco Valeria, Sebastiano Manrico, Costantini David, Pola Gianni & Fusani Leonida, 2021 — Controlled expression of the migratory phenotype affects oxidative status in birds. High caloric intake can increase production of reactive oxygen and nitrogen species. We examined whether the emergence of the… J Exp Biol vol. 224, , jeb233486
ISSN
1477-9145
https://dx.doi.org/10.1242/jeb.233486
Fritze Marcus, Puechmaille Sebastien J., Costantini David, Fickel Jörns, Voigt Christian C. & Czirják Gábor Á, 2021 — Determinants of defence strategies of a hibernating European bat species towards the fungal pathogen Pseudogymnoascus destructans. Pseudogymnoascus destructans (Pd), the causative agent of white-nose syndrome in North America, has decimated bat populations… Dev Comp Immunol vol. 119, , p. 104017
ISSN
1879-0089
https://dx.doi.org/10.1016/j.dci.2021.104017
Rodríguez-Carrillo Andrea, Rosenmai Anna Kjerstine, Mustieles Vicente, Couderq Stephan, Fini Jean-Baptiste, Vela-Soria Fernando, Molina-Molina Jose Manuel, Ferrando-Marco Patricia, Wielsøe Maria, Long Manhai, Bonefeld-Jorgensen Eva Cecilie, Olea Nicolás, Vinggaard Anne Marie & Fernández Mariana F., January 2021 — Assessment of chemical mixtures using biomarkers of combined biological activity: A screening study in human placentas. Reproductive Toxicology , , S0890623821000022
ISSN
08906238
https://dx.doi.org/10.1016/j.reprotox.2021.01.002
Nguyen Duy, Buisine Nicolas, Fayol Olivier, Michels Annemieke A., Bensaude Olivier, Price David H. & Uguen Patricia, August 2021 — An alternative D. melanogaster 7SK snRNP. BACKGROUND: The 7SK small nuclear RNA (snRNA) found in most metazoans is a key regulator of P-TEFb which in turn regulates RNA… BMC Mol Cell Biol vol. 22, n° 1, p. 43
ISSN
2661-8850
https://dx.doi.org/10.1186/s12860-021-00381-7
Luongo Cristina, Butruille Lucile, Sébillot Anthony, LeBlay Karine, Schwaninger Markus, Heuer Heike, Demeneix Barbara A. & Remaud Sylvie, February 2021 — Absence of Both Thyroid Hormone Transporters MCT8 and OATP1C1 Impairs Neural Stem Cell Fate in the Adult Mouse Subventricular Zone. Adult neural stem cell (NSC) generation in vertebrate brains requires thyroid hormones (THs). How THs enter the NSC population… Stem Cell Reports vol. 16, n° 2, p. 337-353
ISSN
2213-6711
https://dx.doi.org/10.1016/j.stemcr.2020.12.009
Fini Jean-Baptiste & Mhaouty-Kodja Sakina, September 2021 — [What about the effects of endocrine disruptors on neurodevelopment?]. Rev Prat. vol. 71, n° 7, p. 735-739
ISSN
2101-017X
Butruille Lucile, Vancamp Pieter, Demeneix Barbara A. & Remaud Sylvie, 2021 — Thyroid hormone regulation of adult neural stem cell fate: A comparative analysis between rodents and primates. Thyroid hormone (TH) signaling, a highly conserved pathway across vertebrates, is crucial for brain development and function… Vitam Horm . vol. 116, , p. 133-192
ISSN
0083-6729
https://dx.doi.org/10.1016/bs.vh.2021.02.009
Dufour Sylvie & Sachs Laurent M., March 2021 — The Chicken and Egg Situation of Thyroid Hormone and Glucocorticoid Signaling during Postembryonic Development. Endocrinology vol. 162, n° 3, bqaa243
ISSN
1945-7170
https://dx.doi.org/10.1210/endocr/bqaa243
Thambirajah Anita A., Wade Michael G., Verreault Jonathan, Buisine Nicolas, Alves Verônica A., Langlois Valerie S. & Helbing Caren C., August 2021 — Disruption by stealth - Interference of endocrine disrupting chemicals on hormonal crosstalk with thyroid axis function in humans and other animals. Thyroid hormones (THs) are important regulators of growth, development, and homeostasis of all vertebrates. There are many… Environ Res vol. 203, , p. 111906
ISSN
1096-0953
https://dx.doi.org/10.1016/j.envres.2021.111906
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  • Faredin ALEJEVSKI
  • Rym AOUCI
  • Nicolas BUISINE
  • Lucile BUTRUILLE
  • David COSTANTINI
  • Stephan COUDERQ
  • Barbara DEMENEIX
  • Jean-Baptiste FINI
  • Anne-Laure GAILLARD
  • Sébastien LE MEVEL
  • Giovanni LEVI
  • Nicolas NARBOUX-NÊME
  • Guillaume PEZERON
  • Sylvie REMAUD
  • Muriel RIGOLET
  • Laurent SACHS
  • Manrico SEBASTIANO
  • Hervé TOSTIVINT
  • Alicia TRIBONDEAU
  • Pieter VANCAMP

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