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PhyMA is a laboratory under the dual supervision of the CNRS (INEE) and the National Museum of Natural History.
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Physiologie moléculaire et adaptation
UMR 7221

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Rodríguez-Carrillo Andrea, Rosenmai Anna Kjerstine, Mustieles Vicente, Couderq Stephan, Fini Jean-Baptiste, Vela-Soria Fernando, Molina-Molina Jose Manuel, Ferrando-Marco Patricia, Wielsøe Maria, Long Manhai, Bonefeld-Jorgensen Eva Cecilie, Olea Nicolás, Vinggaard Anne Marie & Fernández Mariana F., January 2021 — Assessment of chemical mixtures using biomarkers of combined biological activity: A screening study in human placentas. Reproductive Toxicology , , S0890623821000022
ISSN
08906238
https://dx.doi.org/10.1016/j.reprotox.2021.01.002
Nguyen Duy, Buisine Nicolas, Fayol Olivier, Michels Annemieke A., Bensaude Olivier, Price David H. & Uguen Patricia, August 2021 — An alternative D. melanogaster 7SK snRNP. BACKGROUND: The 7SK small nuclear RNA (snRNA) found in most metazoans is a key regulator of P-TEFb which in turn regulates RNA… BMC Mol Cell Biol vol. 22, n° 1, p. 43
ISSN
2661-8850
https://dx.doi.org/10.1186/s12860-021-00381-7
Thambirajah Anita A., Wade Michael G., Verreault Jonathan, Buisine Nicolas, Alves Verônica A., Langlois Valerie S. & Helbing Caren C., August 2021 — Disruption by stealth - Interference of endocrine disrupting chemicals on hormonal crosstalk with thyroid axis function in humans and other animals. Thyroid hormones (THs) are important regulators of growth, development, and homeostasis of all vertebrates. There are many… Environ Res vol. 203, , p. 111906
ISSN
1096-0953
https://dx.doi.org/10.1016/j.envres.2021.111906
Antoine-Lorquin Aymeric, Arensburger Peter, Arnaoty Ahmed, Asgari Sassan, Batailler Martine, Beauclair Linda, Belleannée Catherine, Buisine Nicolas, Coustham Vincent, Guyetant Serge, Helou Laura, Lecomte Thierry, Pitard Bruno, Stévant Isabelle & Bigot Yves, May 2021 — Two repeated motifs enriched within some enhancers and origins of replication are bound by SETMAR isoforms in human colon cells. Setmar is a gene specific to simian genomes. The function(s) of its isoforms are poorly understood and their existence in… Genomics vol. 113, n° 3, p. 1589-1604
ISSN
1089-8646
https://dx.doi.org/10.1016/j.ygeno.2021.03.032
Helou Laura, Beauclair Linda, Dardente Hugues, Arensburger Peter, Buisine Nicolas, Jaszczyszyn Yan, Guillou Florian, Lecomte Thierry, Kentsis Alex & Bigot Yves, April 2021 — The C-terminal Domain of piggyBac Transposase Is Not Required for DNA Transposition. PiggyBac(PB)-like elements (pble) are members of a eukaryotic DNA transposon family. This family is of interest to evolutionary… J Mol Biol vol. 433, n° 7, p. 166805
ISSN
1089-8638
https://dx.doi.org/10.1016/j.jmb.2020.166805
Buisine Nicolas, Grimaldi Alexis, Jonchere Vincent, Rigolet Muriel, Blugeon Corinne, Hamroune Juliette & Sachs Laurent M, 2021 — Transcriptome and Methylome Analysis Reveal Complex Cross-Talks between Thyroid Hormone and Glucocorticoid Signaling at Xenopus Metamorphosis. Background: Most work in endocrinology focus on the action of a single hormone, and very little on the cross-talks between two… Cells vol. 10, n° 9, p. 2375
ISSN
2073-4409
https://dx.doi.org/10.3390/cells10092375
Vancamp Pieter, Spirhanzlova Petra, Sébillot Anthony, Butruille Lucile, Gothié Jean-David, Le Mével Sébastien, Leemans Michelle, Wejaphikul Karn, Meima Marcel, Mughal Bilal B., Roques Pierre, Remaud Sylvie, Fini Jean-Baptiste & Demeneix Barbara A., 2021 — The pyriproxyfen metabolite, 4’-OH-PPF, disrupts thyroid hormone signaling in neural stem cells, modifying neurodevelopmental genes affected by ZIKA virus infection. North-Eastern Brazil saw intensive application of the insecticide pyriproxyfen (PPF) during the microcephaly outbreak caused… Environ Pollut. vol. 285, , p. 117654
ISSN
1873-6424
https://dx.doi.org/10.1016/j.envpol.2021.117654
Messina Simone, Edwards David Paul, Van Houtte Natalie, Tomassi Suzanne, Benedick Suzan, Eens Marcel & Costantini David, 2021 — Impacts of selective logging on haemosporidian infection and physiological correlates in tropical birds. Tropical forest degradation affects host-parasite interactions, determining the probability of animals acquiring an infection… Int J Parasitol. , , S0020–7519(21)00259–9
ISSN
1879-0135
https://dx.doi.org/10.1016/j.ijpara.2021.07.003
Cheron Marion, Costantini David, Angelier Frédéric, Ribout Cécile & Brischoux François, 2021 — Aminomethylphosphonic acid (AMPA) alters oxidative status during embryonic development in an amphibian species. Glyphosate’s primary metabolite (aminomethylphosphonic acid, AMPA) is known to alter embryonic development at environmentally… Chemosphere vol. 287, , p. 131882
ISSN
1879-1298
https://dx.doi.org/10.1016/j.chemosphere.2021.131882
Ohmer Michel E. B., Costantini David, Czirják Gábor Á, Downs Cynthia J., Ferguson Laura V., Flies Andy, Franklin Craig E., Kayigwe Ahab N., Knutie Sarah, Richards-Zawacki Corinne L. & Cramp Rebecca L., 2021 — Applied ecoimmunology: using immunological tools to improve conservation efforts in a changing world. Ecoimmunology is a rapidly developing field that explores how the environment shapes immune function, which in turn influences… Conserv Physiol. vol. 9, n° 1, coab074
ISSN
2051-1434
https://dx.doi.org/10.1093/conphys/coab074
Derakhshan Arash, Shu Huan, Broeren Maarten A. C., Lindh Christian H., Peeters Robin P., Kortenkamp Andreas, Demeneix Barbara, Bornehag Carl-Gustaf & Korevaar Tim I. M., December 2021 — Association of phthalate exposure with thyroid function during pregnancy. BACKGROUND : The extent of thyroid disruptive effects of phthalates during pregnancy remains unclear. AIM: To investigate the… Environ Int. vol. 157, , p. 106795
ISSN
1873-6750
https://dx.doi.org/10.1016/j.envint.2021.106795
Usal Marie, Veyrenc Sylvie, Darracq-Ghitalla-Ciock Marie, Regnault Christophe, Sroda Sophie, Fini Jean-Baptiste, Canlet Cécile, Tremblay-Franco Marie, Raveton Muriel & Reynaud Stéphane, 2021 — Transgenerational metabolic disorders and reproduction defects induced by benzo[a]pyrene in Xenopus tropicalis. Metabolic disorders induced by endocrine disruptors (ED) may contribute to amphibian population declines but no… Environ Pollut vol. 269, , p. 116109
ISSN
1873-6424
https://dx.doi.org/10.1016/j.envpol.2020.116109
Quan Feng B., Gaillard Anne-Laure, Alejevski Faredin, Pézeron Guillaume & Tostivint Hervé, 2021 — Urotensin II-related peptide (Urp) is expressed in motoneurons in zebrafish, but is dispensable for locomotion in larva. The urotensin 2 (uts2) gene family consists of four paralogs called uts2, uts2-related peptide (urp), urp1 and urp2. uts2 is… Peptides vol. 146, , p. 170675
ISSN
1873-5169
https://dx.doi.org/10.1016/j.peptides.2021.170675
Marasco Valeria, Sebastiano Manrico, Costantini David, Pola Gianni & Fusani Leonida, 2021 — Controlled expression of the migratory phenotype affects oxidative status in birds. High caloric intake can increase production of reactive oxygen and nitrogen species. We examined whether the emergence of the… J Exp Biol vol. 224, , jeb233486
ISSN
1477-9145
https://dx.doi.org/10.1242/jeb.233486
Fritze Marcus, Puechmaille Sebastien J., Costantini David, Fickel Jörns, Voigt Christian C. & Czirják Gábor Á, 2021 — Determinants of defence strategies of a hibernating European bat species towards the fungal pathogen Pseudogymnoascus destructans. Pseudogymnoascus destructans (Pd), the causative agent of white-nose syndrome in North America, has decimated bat populations… Dev Comp Immunol vol. 119, , p. 104017
ISSN
1879-0089
https://dx.doi.org/10.1016/j.dci.2021.104017
Tribondeau Alicia, Sachs Laurent M. & Buisine Nicolas, June 2021 — Are paedomorphs actual larvae?. Amphibians display very diverse life cycles and development can be direct, where it occurs in ovo and a juvenile hatches… Dev Dyn vol. 250, n° 6, p. 779-787
ISSN
1097-0177
https://dx.doi.org/10.1002/dvdy.304
Delfosse Vanessa, Huet Tiphaine, Harrus Deborah, Granell Meritxell, Bourguet Maxime, Gardia-Parège Caroline, Chiavarina Barbara, Grimaldi Marina, Le Mével Sébastien, Blanc Pauline, Huang David, Gruszczyk Jakub, Demeneix Barbara, Cianférani Sarah, Fini Jean-Baptiste et al., 2021 — Mechanistic insights into the synergistic activation of the RXR-PXR heterodimer by endocrine disruptor mixtures. Humans are chronically exposed to mixtures of xenobiotics referred to as endocrine-disrupting chemicals (EDCs). A vast body of… Proc Natl Acad Sci USA vol. 118, n° 1, e2020551118
ISSN
1091-6490
https://dx.doi.org/10.1073/pnas.2020551118
Levi Giovanni, de Lombares Camille, Giuliani Cristina, Iannuzzi Vincenzo, Aouci Rym, Garagnani Paolo, Franceschi Claudio, Grimaud-Hervé Dominique & Narboux-Nême Nicolas, 2021 — DLX 5/6 GABAergic expression affects social vocalization: implications for human evolution. DLX 5 and DLX6 are two closely related transcription factors involved in brain development and in GABAergic differentiation… Mol. Biol. Evol. , , msab181
ISSN
1537-1719
https://dx.doi.org/10.1093/molbev/msab181
Costantini David, Masi Shelly, Rachid Lyna, Beltrame Marielle, Rohmer Mélanie & Krief Sabrina, 2021 — Mind the food: rapid changes in antioxidant content of diet affect oxidative status of chimpanzees. The link between dietary antioxidants and oxidative status has been studied extensively in humans. Surprisingly, comparative… Am J Physiol Regul Integr Comp Physiol vol. 320, n° 5, R728–R734
ISSN
1522-1490
https://dx.doi.org/10.1152/ajpregu.00003.2021
Sobrido-Cameán D., Yáñez-Guerra L. A., Deber A., Freire-Delgado M., Cacheiro-Vázquez R., Rodicio M. C., Tostivint H., Anadón R. & Barreiro-Iglesias A., February 2021 — Differential expression of somatostatin genes in the central nervous system of the sea lamprey. The identification of three somatostatin (SST) genes (SSTa, SSTb, and SSTc) in lampreys (Tostivint et al. Gen Comp Endocrinol… Brain Struct Funct , ,
ISSN
1863-2661
https://dx.doi.org/10.1007/s00429-021-02224-9
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  • Rym AOUCI
  • Nicolas BUISINE
  • Lucile BUTRUILLE
  • David COSTANTINI
  • Stephan COUDERQ
  • Barbara DEMENEIX
  • Jean-Baptiste FINI
  • Anne-Laure GAILLARD
  • Sébastien LE MEVEL
  • Giovanni LEVI
  • Nicolas NARBOUX-NÊME
  • Guillaume PEZERON
  • Sylvie REMAUD
  • Muriel RIGOLET
  • Laurent SACHS
  • Manrico SEBASTIANO
  • Hervé TOSTIVINT
  • Alicia TRIBONDEAU
  • Pieter VANCAMP

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  • (-) 2021

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  • DESYNE
  • RODEO

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  • (-) MNHN

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