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PhyMA is a laboratory under the dual supervision of the CNRS (INEE) and the National Museum of Natural History.
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Physiologie moléculaire et adaptation
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Vancamp Pieter, Gothié Jean-David, Luongo Cristina, Sébillot Anthony, Le Blay Karine, Butruille Lucile, Pagnin Maurice, Richardson Samantha J., Demeneix Barbara A. & Remaud Sylvie, 2019 — Gender-specific effects of transthyretin on neural stem cell fate in the subventricular zone of the adult mouse. Choroid plexus epithelial cells produce and secrete transthyretin (TTR). TTR binds and distributes thyroid hormone (TH) to… Sci Rep vol. 9, n° 1, p. 19689
ISSN
2045-2322
https://dx.doi.org/10.1038/s41598-019-56156-w
Valcárcel-Hernández Víctor, Vancamp Pieter, Butruille Lucile, Remaud Sylvie & Guadaño-Ferraz Ana, June 2024 — Combined deletion of Mct8 and Dio2 impairs SVZ neurogliogenesis and olfactory function in adult mice. Within the adult mouse subventricular zone (SVZ), neural stem cells (NSCs) produce neuroblasts and oligodendrocyte precursor… Neurobiology of Disease vol. 199, , p. 106572
ISSN
1095-953X
https://dx.doi.org/10.1016/j.nbd.2024.106572
Butruille L., Jubin P., Martin E., Aigrot M. S., Lhomme M., Fini J. B., Demeneix B., Stankoff B., Lubetzki C., Zalc B. & Remaud S., September 2023 — Deleterious functional consequences of perfluoroalkyl substances accumulation into the myelin sheath. Exposure to persistent organic pollutants during the perinatal period is of particular concern because of the potential… vol. 180, , p. 108211
ISSN
1873-6750
https://dx.doi.org/10.1016/j.envint.2023.108211
Vancamp Pieter, Spirhanzlova Petra, Sébillot Anthony, Butruille Lucile, Gothié Jean-David, Le Mével Sébastien, Leemans Michelle, Wejaphikul Karn, Meima Marcel, Mughal Bilal B., Roques Pierre, Remaud Sylvie, Fini Jean-Baptiste & Demeneix Barbara A., 2021 — The pyriproxyfen metabolite, 4’-OH-PPF, disrupts thyroid hormone signaling in neural stem cells, modifying neurodevelopmental genes affected by ZIKA virus infection. North-Eastern Brazil saw intensive application of the insecticide pyriproxyfen (PPF) during the microcephaly outbreak caused… Environ Pollut. vol. 285, , p. 117654
ISSN
1873-6424
https://dx.doi.org/10.1016/j.envpol.2021.117654
Valcarcel-Hernandez V., Butruille L. & Remaud S., December 2025 — Effects of thyroid disruption on neural cells stem fate in the mouse brain. Thyroid hormones (THs), particularly T3 and T4, play crucial roles in neural development and maintenance by regulating neural… Presse Medicale vol. 54, n° 4, p. 104312
ISSN
2213-0276
https://dx.doi.org/10.1016/j.lpm.2025.104312
Butruille L., Guittonneau C., Le Blay K., Valcarcel V., Aigrot M. S., Fini J. B., Zalc B. & Remaud S., July 2026 — Early-life PFOS exposure causes lasting impairment of neural stem cell fate, white matter maturation, and olfactory behavior. Per- and polyfluoroalkyl substances (PFAS) are widespread and persistent environmental pollutants that bioaccumulate and are… Ecotoxicol Environ Saf vol. 320, , p. 120365
ISSN
1090-2414
https://dx.doi.org/10.1016/j.ecoenv.2026.120365
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  • Barbara DEMENEIX
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