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PhyMA is a laboratory under the dual supervision of the CNRS (INEE) and the National Museum of Natural History.
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Physiologie moléculaire et adaptation
UMR 7221

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Louis Emeric, Fu Liezhen, Shi Yun-Bo & Sachs Laurent M, September 2024 — Functions and Mechanism of Thyroid Hormone Receptor Action During Amphibian Development. Abstract Thyroid hormones and their receptors (TRs) play critical roles during vertebrate development. One of the most dramatic… Endocrinology vol. 165, n° 11, bqae137
ISSN
1945-7170
https://dx.doi.org/10.1210/endocr/bqae137
Carrara Mathieu, Gaillard Anne-Laure, Brion Alice, Duvernois-Berthet Evelyne, Giovannangeli Carine, Concordet Jean-Paul & Pézeron Guillaume, February 2025 — Dynamic interplay of cNHEJ and MMEJ pathways of DNA double-strand break repair during embryonic development in zebrafish. Double strand breaks (DSBs) are the most deleterious DNA lesions as they frequently result in mutations when repaired by… Scientific Reports vol. 15, n° 1, p. 4886
ISSN
2045-2322
https://dx.doi.org/10.1038/s41598-025-88564-6
Sapounidou Maria, Andersson Patrik L., Leemans Michelle, Fini Jean-Baptiste, Demeneix Barbara, Rüegg Joëlle, Bornehag Carl-Gustaf & Gennings Chris, March 2023 — From Cohort to Cohort: A Similar Mixture Approach (SMACH) to Evaluate Exposures to a Mixture Leading to Thyroid-Mediated Neurodevelopmental Effects Using NHANES Data. Prenatal exposure to a mixture (MIX N) of eight endocrine-disrupting chemicals has been associated with language delay in… Toxics vol. 11, n° 4, p. 331
ISSN
2305-6304
https://dx.doi.org/10.3390/toxics11040331
Lazcano I., Olvera A., Pech-Pool S. M., Sachs L., Buisine N. & Orozco A., 2023 — Differential effects of 3,5-T2 and T3 on the gill regeneration and metamorphosis of the Ambystoma mexicanum (axolotl). Thyroid hormones (THs) regulate tissue remodeling processes during early- and post-embryonic stages in vertebrates. The Mexican… Front Endocrinol (Lausanne) vol. 14, , p. 1208182
ISSN
1664-2392
https://dx.doi.org/10.3389/fendo.2023.1208182
Derakhshan Arash, Shu Huan, Broeren Maarten A. C., Kortenkamp Andreas, Lindh Christian H., Demeneix Barbara, Peeters Robin P., Bornehag Carl-Gustaf & Korevaar Tim I. M., July 2023 — Association of endocrine disrupting chemicals exposure with human chorionic gonadotropin concentrations in pregnancy. BACKGROUND: Human chorionic gonadotropin (hCG) is produced by the placenta and plays an essential role in the maintenance of… Environ Int vol. 178, , p. 108091
ISSN
1873-6750
https://dx.doi.org/10.1016/j.envint.2023.108091
Butruille L., Jubin P., Martin E., Aigrot M. S., Lhomme M., Fini J. B., Demeneix B., Stankoff B., Lubetzki C., Zalc B. & Remaud S., September 2023 — Deleterious functional consequences of perfluoroalkyl substances accumulation into the myelin sheath. Exposure to persistent organic pollutants during the perinatal period is of particular concern because of the potential… vol. 180, , p. 108211
ISSN
1873-6750
https://dx.doi.org/10.1016/j.envint.2023.108211
Krief Sabrina, Spirhanzlova Petra, Masi Shelly, Couturier Chloé, Okwir Eric, Asalu Edward, Bustamante Paco & Costantini David, November 2023 — High urinary oxidative DNA damage in wild chimpanzees ranging in proximity of agricultural fields in Sebitoli area, Uganda. Agriculture expansion is a major cause of habitat loss and exposure to phytochemical pollution for non-human primates. In… vol. 30, n° 51, p. 110600-110611
ISSN
1614-7499
https://dx.doi.org/10.1007/s11356-023-30187-3
Ullrich Simon, Leidescher Susanne, Feodorova Yana, Thanisch Katharina, Fini Jean-Baptiste, Kaspers Bernd, Weber Frank, Markova Boyka, Führer Dagmar, Romitti Mirian, Krebs Stefan, Blum Helmut, Leonhardt Heinrich, Costagliola Sabine, Heuer Heike et al., 2023 — The highly and perpetually upregulated thyroglobulin gene is a hallmark of functional thyrocytes. Abnormalities are indispensable for studying normal biological processes and mechanisms. In the present work, we draw attention… vol. 11, , p. 1265407
ISSN
2296-634X
https://dx.doi.org/10.3389/fcell.2023.1265407
Rannaud-Bartaire Patricia & Fini Jean-Baptiste, 2023 — [Disruptors of thyroid hormones: Which consequences for human health and environment?]. Endocrine disruptors (EDs) of chemical origin are the subject of numerous studies, some of which have led to measures aimed at… Bioogie Aujourd'hui vol. 217, n° 3, p. 219-231
ISSN
2105-0686
https://dx.doi.org/10.1051/jbio/2023036
Pesce Elise, Garde Marion, Rigolet Muriel, Tindall Andrew J., Lemkine Gregory F., Baumann Lisa A., Sachs Laurent M. & Du Pasquier David, December 2023 — A Novel Transgenic Model to Study Thyroid Axis Activity in Early Life Stage Medaka. Identifying endocrine disrupting chemicals in order to limit their usage is a priority and required according to the European… Environ. Sci. Technol. , ,
ISSN
1520-5851
https://dx.doi.org/10.1021/acs.est.3c05515
Etienne Marchand, Fabienne Petit, Fabrice Alliot, Hélène Blanchoud, David Costantini, Elodie Guigon, Nicolas Martin, Sira Traore & Aurélie Goutte, December 2023 — Contrasted Antibiotics and Pesticides Impregnation in Fish Exposed in situ to Urban Effluents: A 20-Day Caging Experiment. Urban freshwater ecosystems receive a wide array of organic pollutants through wastewater treatment plant (WWTP) discharges and… Environ Toxicol Chem , ,
ISSN
1552-8618
https://dx.doi.org/10.1002/etc.5810
Rannaud-Bartaire Patricia, Demeneix Barbara A. & Fini Jean-Baptiste, December 2023 — Pressures of the urban environment on the endocrine system: Adverse effects and adaptation. With an increasing collective awareness of the rapid environmental changes, questions and theories regarding the adaptability… Mol. Cell. Endocrinol. , , p. 112125
ISSN
1872-8057
https://dx.doi.org/10.1016/j.mce.2023.112125
Bredeson Jessen V., Mudd Austin B., Medina-Ruiz Sofia, Mitros Therese, Smith Owen Kabnick, Miller Kelly E., Lyons Jessica B., Batra Sanjit S., Park Joseph, Berkoff Kodiak C., Plott Christopher, Grimwood Jane, Schmutz Jeremy, Aguirre-Figueroa Guadalupe, Khokha Mustafa K. et al., January 2024 — Conserved chromatin and repetitive patterns reveal slow genome evolution in frogs. Frogs are an ecologically diverse and phylogenetically ancient group of anuran amphibians that include important vertebrate… Nat. Commun. vol. 15, n° 1, p. 579
ISSN
2041-1723
https://dx.doi.org/10.1038/s41467-023-43012-9
Luongo Cristina, Butruille Lucile, Sébillot Anthony, LeBlay Karine, Schwaninger Markus, Heuer Heike, Demeneix Barbara A. & Remaud Sylvie, February 2021 — Absence of Both Thyroid Hormone Transporters MCT8 and OATP1C1 Impairs Neural Stem Cell Fate in the Adult Mouse Subventricular Zone. Adult neural stem cell (NSC) generation in vertebrate brains requires thyroid hormones (THs). How THs enter the NSC population… Stem Cell Reports vol. 16, n° 2, p. 337-353
ISSN
2213-6711
https://dx.doi.org/10.1016/j.stemcr.2020.12.009
Tostivint Hervé, Alejevski Faredin, Leemans Michelle, Gaillard Anne-Laure, Le Mével Sébastien, Herrel Anthony, Fini Jean-Baptiste & Pézeron Guillaume, January 2022 — [Neuropeptides involved in proper spine morphogenesis: Lessons from fish and toad]. Médecine Sciences vol. 38, n° 1, p. 27-29
ISSN
1958-5381
https://dx.doi.org/10.1051/medsci/2021236
Gaillard Anne-Laure, Mohamad Teddy, Quan Feng B., de Cian Anne, Mosimann Christian, Tostivint Hervé & Pézeron Guillaume, February 2023 — Urp1 and Urp2 act redundantly to maintain spine shape in zebrafish larvae. Developmental Biology , , S0012160623000180
ISSN
00121606
https://dx.doi.org/10.1016/j.ydbio.2023.01.010
Tostivint Hervé, Girardot Fabrice, Parmentier Caroline & Pézeron Guillaume, 2022 — [The caudal neurosecretory system, the other "neurohypophysial" system in fish]. The caudal neurosecretory system (CNSS) is a neuroendocrine complex whose existence is specific to fishes. Structurally, it… Biologie Aujourd'hui vol. 216, n° 3, p. 89-103
ISSN
2105-0686
https://dx.doi.org/10.1051/jbio/2022016
Deprouw Camille, Courties Alice, Fini Jean-Baptiste, Clerget-Froidevaux Marie-Stéphanie, Demeneix Barbara, Berenbaum Francis, Sellam Jérémie & Louati Karine, June 2022 — Pollutants: a candidate as a new risk factor for osteoarthritis-results from a systematic literature review. BACKGROUND : Considering non-classical environmental risk factors for osteoarthritis (OA), a systematic literature review … RMD Open vol. 8, n° 2, e001983
ISSN
2056-5933
https://dx.doi.org/10.1136/rmdopen-2021-001983
Leemans Michelle, Spirhanzlova Petra, Couderq Stephan, LeMével Sébastien, Grimaldi Alexis, Duvernois-Berthet Evelyne, Demeneix Barbara & Fini Jean-Baptiste, January 2023 — A Mixture of Chemicals Found in Human Amniotic Fluid Disrupts Brain Gene Expression and Behavior in Xenopus laevis. Thyroid hormones (TH) are essential for normal brain development, influencing neural cell differentiation, migration, and… Int J Mol Sci. vol. 24, n° 3, p. 2588
ISSN
1422-0067
https://dx.doi.org/10.3390/ijms24032588
Boisard Julie, Duvernois-Berthet Evelyne, Duval Linda, Schrével Joseph, Guillou Laure, Labat Amandine, Le Panse Sophie, Prensier Gérard, Ponger Loïc & Florent Isabelle, July 2022 — Marine gregarine genomes reveal the breadth of apicomplexan diversity with a partially conserved glideosome machinery. Our current view of the evolutionary history, coding and adaptive capacities of Apicomplexa, protozoan parasites of a wide… BMC Genomics vol. 23, n° 1, p. 485
ISSN
1471-2164
https://dx.doi.org/10.1186/s12864-022-08700-8
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