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Physiologie moléculaire et adaptation
UMR 7221

Recherche

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Du Pasquier D., Rincheval V., Sinzelle L., Chesneau A., Ballagny C., Sachs L. M., Demeneix B. & Mazabraud A., août 2006 — Developmental cell death during Xenopus metamorphosis involves BID cleavage and caspase 2 and 8 activation. Dev. Dyn. vol. 235, n° 8, p. 2083-2094
ISSN
1058-8388
https://dx.doi.org/10.1002/dvdy.20874
Vancamp Pieter, Spirhanzlova Petra, Sébillot Anthony, Butruille Lucile, Gothié Jean-David, Le Mével Sébastien, Leemans Michelle, Wejaphikul Karn, Meima Marcel, Mughal Bilal B., Roques Pierre, Remaud Sylvie, Fini Jean-Baptiste & Demeneix Barbara A., 2021 — The pyriproxyfen metabolite, 4’-OH-PPF, disrupts thyroid hormone signaling in neural stem cells, modifying neurodevelopmental genes affected by ZIKA virus infection. North-Eastern Brazil saw intensive application of the insecticide pyriproxyfen (PPF) during the microcephaly outbreak caused… Environ Pollut. vol. 285, , p. 117654
ISSN
1873-6424
https://dx.doi.org/10.1016/j.envpol.2021.117654
Derakhshan Arash, Shu Huan, Broeren Maarten A. C., Lindh Christian H., Peeters Robin P., Kortenkamp Andreas, Demeneix Barbara, Bornehag Carl-Gustaf & Korevaar Tim I. M., décembre 2021 — Association of phthalate exposure with thyroid function during pregnancy. BACKGROUND : The extent of thyroid disruptive effects of phthalates during pregnancy remains unclear. AIM: To investigate the… Environ Int. vol. 157, , p. 106795
ISSN
1873-6750
https://dx.doi.org/10.1016/j.envint.2021.106795
Kortenkamp Andreas, Axelstad Marta, Baig Asma H., Bergman Åke, Bornehag Carl-Gustaf, Cenijn Peter, Christiansen Sofie, Demeneix Barbara, Derakhshan Arash, Fini Jean-Baptiste, Frädrich Caroline, Hamers Timo, Hellwig Lina, Köhrle Josef, Korevaar Tim I. M. et al., 2020 — Removing Critical Gaps in Chemical Test Methods by Developing New Assays for the Identification of Thyroid Hormone System-Disrupting Chemicals-The ATHENA Project. The test methods that currently exist for the identification of thyroid hormone system-disrupting chemicals are woefully… Int J Mol Sci vol. 21, n° 9, E3123
ISSN
1422-0067
https://dx.doi.org/10.3390/ijms21093123
Demeneix Barbara A., décembre 2019 — Evidence for Prenatal Exposure to Thyroid Disruptors and Adverse Effects on Brain Development. Thyroid hormone regulates vital processes in early brain development such as neuronal stem cell proliferation, migration, and… Eur Thyroid J vol. 8, n° 6, p. 283-292
ISSN
2235-0640
https://dx.doi.org/10.1159/000504668
Leemans Michelle, Couderq Stephan, Demeneix Barbara & Fini Jean-Baptiste, 2019 — Pesticides With Potential Thyroid Hormone-Disrupting Effects: A Review of Recent Data. Plant Protection Products, more commonly referred to as pesticides and biocides, are used to control a wide range of yield… Front Endocrinol (Lausanne) vol. 10, , p. 743
ISSN
1664-2392
https://dx.doi.org/10.3389/fendo.2019.00743
Remaud Sylvie & Demeneix Barbara, 2019 — [Thyroid hormones regulate neural stem cell fate]. Thyroid hormones (THs) are vital for vertebrate brain function throughout life, from early development to ageing… Biol Aujourdhui vol. 213, n° 1, p. 7-16
ISSN
2105-0686
https://dx.doi.org/10.1051/jbio/2019007
Gothié Jean-David, Vancamp Pieter, Demeneix Barbara & Remaud Sylvie, 2020 — Thyroid hormone regulation of neural stem cell fate: From development to ageing. In the vertebrate brain, neural stem cells (NSCs) generate both neuronal and glial cells throughout life. However, their neuro… Acta Physiol (Oxf) vol. 228, n° 1, e13316
ISSN
1748-1716
https://dx.doi.org/10.1111/apha.13316
Spirhanzlova Petra, Fini Jean-Baptiste, Demeneix Barbara, Lardy-Fontan Sophie, Vaslin-Reimann Sophie, Lalere Béatrice, Guma Nelson, Tindall Andrew & Krief Sabrina, août 2019 — Composition and endocrine effects of water collected in the Kibale national park in Uganda. Pesticides are used worldwide with potential harmful effects on both fauna and flora. The Kibale National Park in Uganda, a… Environ. Pollut. vol. 251, , p. 460-468
ISSN
1873-6424
https://dx.doi.org/10.1016/j.envpol.2019.05.006
Mughal Bilal B., Leemans Michelle, Spirhanzlova Petra, Demeneix Barbara & Fini Jean-Baptiste, 2018 — Reference gene identification and validation for quantitative real-time PCR studies in developing Xenopus laevis. Reference genes are essential for gene expression analysis when using real-time quantitative PCR (RT-qPCR). Xenopus laevis is… Sci Rep vol. 8, n° 1, p. 496
ISSN
2045-2322
https://dx.doi.org/10.1038/s41598-017-18684-1
Demeneix Barbara, Vandenberg Laura N., Ivell Richard & Zoeller R. Thomas, octobre 2020 — Thresholds and Endocrine Disruptors: An Endocrine Society Policy Perspective. The concept of a threshold of adversity in toxicology is neither provable nor disprovable. As such, it is not a scientific… J Endocr Soc . vol. 4, n° 10, bvaa085
ISSN
2472-1972
https://dx.doi.org/10.1210/jendso/bvaa085
Landrigan Philip J., Stegeman John J., Fleming Lora E., Allemand Denis, Anderson Donald M., Backer Lorraine C., Brucker-Davis Françoise, Chevalier Nicolas, Corra Lilian, Czerucka Dorota, Bottein Marie-Yasmine Dechraoui, Demeneix Barbara, Depledge Michael, Deheyn Dimitri D., Dorman CharlesJ. et al., 2020 — Human Health and Ocean Pollution. Background: Pollution - unwanted waste released to air, water, and land by human activity - is the largest environmental cause… Ann Glob Health vol. 86, n° 1, p. 151
ISSN
2214-9996
https://dx.doi.org/10.5334/aogh.2831
Delfosse Vanessa, Huet Tiphaine, Harrus Deborah, Granell Meritxell, Bourguet Maxime, Gardia-Parège Caroline, Chiavarina Barbara, Grimaldi Marina, Le Mével Sébastien, Blanc Pauline, Huang David, Gruszczyk Jakub, Demeneix Barbara, Cianférani Sarah, Fini Jean-Baptiste et al., 2021 — Mechanistic insights into the synergistic activation of the RXR-PXR heterodimer by endocrine disruptor mixtures. Humans are chronically exposed to mixtures of xenobiotics referred to as endocrine-disrupting chemicals (EDCs). A vast body of… Proc Natl Acad Sci USA vol. 118, n° 1, e2020551118
ISSN
1091-6490
https://dx.doi.org/10.1073/pnas.2020551118
Lupu Diana, Andersson Patrik, Bornehag Carl-Gustaf, Demeneix Barbara, Fritsche Ellen, Gennings Chris, Lichtensteiger Walter, Leist Marcel, Leonards Pim E. G., Ponsonby Anne-Louise, Scholze Martin, Testa Giuseppe, Tresguerres Jesus A. F., Westerink Remco H. S., Zalc Bernard et al., juin 2020 — The ENDpoiNTs Project: Novel Testing Strategies for Endocrine Disruptors Linked to Developmental Neurotoxicity. Ubiquitous exposure to endocrine-disrupting chemicals (EDCs) has caused serious concerns about the ability of these chemicals… Int J Mol Sci vol. 21, n° 11, p. 3978
ISSN
1422-0067
https://dx.doi.org/10.3390/ijms21113978
Krief Sabrina, Iglesias-González Alba, Appenzeller Brice MarcRené, Okimat John Paul, Fini Jean-Baptiste, Demeneix Barbara, Vaslin-Reimann Sophie, Lardy-Fontan Sophie, Guma Nelson & Spirhanzlova Petra, mai 2020 — Road impact in a protected area with rich biodiversity: the case of the Sebitoli road in Kibale National Park, Uganda. While road network expansion is crucial for economic development, it can cause a notable disturbance of fauna, especially in… Environ Sci Pollut Res Int vol. 27, n° 22, p. 27914-27925
ISSN
1614-7499
https://dx.doi.org/10.1007/s11356-020-09098-0
Vancamp Pieter, Le Blay Karine, Butruille Lucile, Sébillot Anthony, Boelen Anita, Demeneix Barbara A. & Remaud Sylvie, mars 2022 — Developmental thyroid disruption permanently affects the neuroglial output in the murine subventricular zone. Neural stem cells (NSCs) in the adult brain are a source of neural cells for brain injury repair. We investigated whether… Stem Cell Reports vol. 17, n° 3, p. 459-474
ISSN
2213-6711
https://dx.doi.org/10.1016/j.stemcr.2022.01.002
Luongo Cristina, Butruille Lucile, Sébillot Anthony, LeBlay Karine, Schwaninger Markus, Heuer Heike, Demeneix Barbara A. & Remaud Sylvie, février 2021 — Absence of Both Thyroid Hormone Transporters MCT8 and OATP1C1 Impairs Neural Stem Cell Fate in the Adult Mouse Subventricular Zone. Adult neural stem cell (NSC) generation in vertebrate brains requires thyroid hormones (THs). How THs enter the NSC population… Stem Cell Reports vol. 16, n° 2, p. 337-353
ISSN
2213-6711
https://dx.doi.org/10.1016/j.stemcr.2020.12.009
Deprouw Camille, Courties Alice, Fini Jean-Baptiste, Clerget-Froidevaux Marie-Stéphanie, Demeneix Barbara, Berenbaum Francis, Sellam Jérémie & Louati Karine, juin 2022 — Pollutants: a candidate as a new risk factor for osteoarthritis-results from a systematic literature review. BACKGROUND : Considering non-classical environmental risk factors for osteoarthritis (OA), a systematic literature review … RMD Open vol. 8, n° 2, e001983
ISSN
2056-5933
https://dx.doi.org/10.1136/rmdopen-2021-001983
Leemans Michelle, Spirhanzlova Petra, Couderq Stephan, LeMével Sébastien, Grimaldi Alexis, Duvernois-Berthet Evelyne, Demeneix Barbara & Fini Jean-Baptiste, janvier 2023 — A Mixture of Chemicals Found in Human Amniotic Fluid Disrupts Brain Gene Expression and Behavior in Xenopus laevis. Thyroid hormones (TH) are essential for normal brain development, influencing neural cell differentiation, migration, and… Int J Mol Sci. vol. 24, n° 3, p. 2588
ISSN
1422-0067
https://dx.doi.org/10.3390/ijms24032588
Vancamp Pieter, Butruille Lucile, Herranen Anni, Boelen Anita, Fini Jean-Baptiste, Demeneix Barbara A. & Remaud Sylvie, janvier 2023 — Transient developmental exposure to low doses of bisphenol F negatively affects neurogliogenesis and olfactory behaviour in adult mice. Neural stem cells in the murine subventricular zone (SVZ) reactivate during postnatal development to generate neurons and glia… Environ Int . vol. 172, , p. 107770
ISSN
1873-6750
https://dx.doi.org/10.1016/j.envint.2023.107770
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  • Lucile BUTRUILLE
  • Marie-Stéphanie CLERGET-FROIDEVAUX
  • Laurent COEN
  • Stephan COUDERQ
  • Evelyne DUVERNOIS-BERTHET
  • Jean-Baptiste FINI
  • Fabrice GIRARDOT
  • Anni HERRANEN
  • Karine LE BLAY
  • Michelle LEEMANS
  • Sébastien LE MEVEL
  • Giovanni LEVI
  • Sylvie REMAUD
  • Laurent SACHS
  • Isabelle SEUGNET
  • Pieter VANCAMP
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