PhyMA est une Unité Mixte de Recherche CNRS-MNHN (UMR 7221).
Giovanni LEVI
Giovanni LEVI
Directeur de Recherche émérite
Chargé(e) d’enseignement
Entité de rattachement
BBC
Thème interdisciplinaire de recherche
Ageing, Neuroscience
Spécialité
Developmental Biology
Contact
Réseaux sociaux
Courriel
Téléphone
+33609162640
Fax
01 40 79 36 18
Adresse(s)
7 rue Cuvier
75005 Paris
Responsabilités hors unité
Editor of Scientific Reports, Cells, Frontiers in Cell and Developmental Biology
Projets
ANR METABRAIN 2022-2026. Role of DLX5/6 in GABAergic neurons: deciphering metabolism/behavior interplay
Metabolic status is one of the major determinants of healthy aging and life expectancy. The brain controls metabolism through the activity of neuronal networks that integrate hormonal signals from peripheral organs and induce behavioral and metabolic responses. We have shown that Dlx5/6 expression in mouse GABAergic neurons simultaneously affects behavior and metabolism, with a significant extension of healthspan and lifespan. The aim of METABRAIN is to start from these observations to gain better insight into the brain/body interactions linking energy homeostasis to cognitive capacities. The effects of modulation of Dlx5/6 expression in GABAergic neurons on behavioral and metabolic profiles will be analyzed in depth. The contribution of different parts of the brain will be established through region-specific Dlx5/6 invalidation and overexpression. Single-nuclei RNA-Seq, ChIP-Seq, and ATAC-Seq will be used to define the mode of action of Dlx5/6 in GABAergic neurons.
Role in the project: Coordinator
ANR TARGETBONE 2018-2022 New TARGETs for osteoporosis: from mesenchymal stem cells to the regulation of osteogenesis and BONE mass
TARGETBONE wants to expand our understanding of the cellular and molecular mechanisms at the origin of osteoporosis. TARGETBONE will focus on understanding how the differentiation of mesenchymal progenitors towards the osteoblastic lineage is regulated. We will follow the initial lead provided by our observations on the central role of the two transcription factors Dlx5 and Dlx6 in the control of osteogenesis. Dlx5 and Dlx6 are expressed by mesenchymal precursors and are upstream regulators of Runx2 and Osterix, two master genes of osteogenesis. We want to characterize functionally and molecularly the dynamic regulatory network controlling mesenchymal stem cells differentiation into the osteoblast lineage. Our ambition is to identify new targets to stimulate osteogenesis and tackle osteoporosis.
Publications
2022
- , Octobre 2022 — DLX Genes in the Development and Maintenance of the Vertebrate Skeleton: Implications for Human Pathologies. Skeletal shape and mechanical properties define, to a large extent, vertebrate morphology and physical capacities. During... Cells. Vol. 11, n° 20, p. 3277.ISSN:2073-4409
- , 2022 — Distal-less homeobox genes Dlx5/6 regulate Müllerian duct regression. Dlx5 and Dlx6 encode distal-less homeodomain transcription factors that are present in the genome as a linked pair at a single... Frontiers in Endocrinology. Vol. 13, p. 916173.ISSN:1664-2392
2021
- , 2021 — DLX 5/6 GABAergic expression affects social vocalization: implications for human evolution. DLX 5 and DLX6 are two closely related transcription factors involved in brain development and in GABAergic differentiation... Mol. Biol. Evol. Msab181.ISSN:1537-1719
2019
- , Septembre 2019 — Dlx5 and Dlx6 expression in GABAergic neurons controls behavior, metabolism, healthy aging and lifespan. Aging (Albany NY). Vol. 11, n° 17, p. 6638-6656.ISSN:1945-4589
- , 2019 — Posterior axis formation requires Dlx5/Dlx6 expression at the neural plate border. PLoS ONE. Vol. 14, n° 3, e0214063.ISSN:1932-6203
2018
- , Octobre 2018 — Probing the origin of matching functional jaws: roles of Dlx5/6 in cranial neural crest cells. Sci Rep. Vol. 8, n° 1, p. 14975.ISSN:2045-2322
- , 2018 — Comparative analysis of molecular signatures suggests the use of gabapentin for the management of endometriosis-associated pain. J Pain Res. Vol. 11, p. 715-725.ISSN:1178-7090
2016
- , Janvier 2016 — Dlx5 and Dlx6 control uterine adenogenesis during post-natal maturation: possible consequences for endometriosis. Hum. Mol. Genet. Vol. 25, n° 1, p. 97-108.ISSN:1460-2083
2015
- , Juin 2015 — Role of Foxl2 in uterine maturation and function. Hum. Mol. Genet. Vol. 24, n° 11, p. 3092-3103.ISSN:1460-2083
- , Juin 2015 — Distinct effects of Hoxa2 overexpression in cranial neural crest populations reveal that the mammalian hyomandibular-ceratohyal boundary maps within the styloid process. Dev. Biol. Vol. 402, n° 2, p. 162-174.ISSN:1095-564X