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PhyMA is a laboratory under the dual supervision of the CNRS (INEE) and the National Museum of Natural History.
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Physiologie moléculaire et adaptation
UMR 7221

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Fritze Marcus, Puechmaille Sebastien J., Costantini David, Fickel Jörns, Voigt Christian C. & Czirják Gábor Á, 2021 — Determinants of defence strategies of a hibernating European bat species towards the fungal pathogen Pseudogymnoascus destructans. Pseudogymnoascus destructans (Pd), the causative agent of white-nose syndrome in North America, has decimated bat populations… Dev Comp Immunol vol. 119, , p. 104017
ISSN
1879-0089
https://dx.doi.org/10.1016/j.dci.2021.104017
Sebastiano Manrico, Canestrelli Daniele, Bisconti Roberta, Lavergne Anne, Pineau Kévin, Chastel Olivier, Lacoste Vincent & Costantini David, 2020 — Detection and Phylogenetic Characterization of a Novel Herpesvirus in Sooty Terns Onychoprion fuscatus. Since 2005, we have recorded annual episodes of alphaherpesvirus outbreaks in chicks of magnificent frigatebird Fregata… Front Vet Sci. vol. 7, , p. 567
ISSN
2297-1769
https://dx.doi.org/10.3389/fvets.2020.00567
Liparoto Anita, Canestrelli Daniele, Bisconti Roberta, Carere Claudio & Costantini David, 2020 — Biogeographic history moulds population differentiation in ageing of oxidative status in an amphibian. Regulation of oxidative status plays a substantial role in physiological ageing. However, we know little about age-related… J Exp Biol vol. 223, , jeb235002
ISSN
1477-9145
https://dx.doi.org/10.1242/jeb.235002
Soldatini Cecilia, Sebastiano Manrico, Albores-Barajas Yuri V., Abdelgawad Hamada, Bustamante Paco & Costantini David, March 2020 — Mercury exposure in relation to foraging ecology and its impact on the oxidative status of an endangered seabird. Mercury is a natural element extensively found in the Earth’s crust, released to the atmosphere and waters by natural processes… Sci. Total Environ. vol. 724, , p. 138131
ISSN
1879-1026
https://dx.doi.org/10.1016/j.scitotenv.2020.138131
Levi Giovanni, de Lombares Camille, Giuliani Cristina, Iannuzzi Vincenzo, Aouci Rym, Garagnani Paolo, Franceschi Claudio, Grimaud-Hervé Dominique & Narboux-Nême Nicolas, 2021 — DLX 5/6 GABAergic expression affects social vocalization: implications for human evolution. DLX 5 and DLX6 are two closely related transcription factors involved in brain development and in GABAergic differentiation… Mol. Biol. Evol. , , msab181
ISSN
1537-1719
https://dx.doi.org/10.1093/molbev/msab181
Costantini David, Masi Shelly, Rachid Lyna, Beltrame Marielle, Rohmer Mélanie & Krief Sabrina, 2021 — Mind the food: rapid changes in antioxidant content of diet affect oxidative status of chimpanzees. The link between dietary antioxidants and oxidative status has been studied extensively in humans. Surprisingly, comparative… Am J Physiol Regul Integr Comp Physiol vol. 320, n° 5, R728–R734
ISSN
1522-1490
https://dx.doi.org/10.1152/ajpregu.00003.2021
Sebastiano Manrico, Costantini David, Eens Marcel, Pineau Kevin, Bustamante Paco & Chastel Olivier, June 2022 — Possible interaction between exposure to environmental contaminants and nutritional stress in promoting disease occurrence in seabirds from French Guiana: a review. Reg Environ Change vol. 22, n° 2, p. 63
ISSN
1436-3798, 1436-378X
https://dx.doi.org/10.1007/s10113-022-01914-2
Aouci Rym, El Soudany Mey, Maakoul Zakaria, Fontaine Anastasia, Kurihara Hiroki, Levi Giovanni & Narboux-Nême Nicolas, May 2022 — Dlx5/6 Expression Levels in Mouse GABAergic Neurons Regulate Adult Parvalbumin Neuronal Density and Anxiety/Compulsive Behaviours. Neuronal circuits integrating Parvalbumin-positive GABAergic inhibitory interneurons (PV) are essential for normal brain… Cells vol. 11, n° 11, p. 1739
ISSN
2073-4409
https://dx.doi.org/10.3390/cells11111739
Chamas Lamis, Seugnet Isabelle, Poirier Roseline, Clerget-Froidevaux Marie-Stéphanie & Enderlin Valérie, October 2022 — A Fine Regulation of the Hippocampal Thyroid Signalling Protects Hypothyroid Mice against Glial Cell Activation. Adult-onset hypothyroidism is associated with learning and cognitive dysfunctions, which may be related to alterations in… International Journal of Molecular Sciences vol. 23, n° 19, p. 11938
ISSN
1422-0067
https://dx.doi.org/10.3390/ijms231911938
Vancamp Pieter, Le Blay Karine, Butruille Lucile, Sébillot Anthony, Boelen Anita, Demeneix Barbara A. & Remaud Sylvie, March 2022 — Developmental thyroid disruption permanently affects the neuroglial output in the murine subventricular zone. Neural stem cells (NSCs) in the adult brain are a source of neural cells for brain injury repair. We investigated whether… Stem Cell Reports vol. 17, n° 3, p. 459-474
ISSN
2213-6711
https://dx.doi.org/10.1016/j.stemcr.2022.01.002
Luongo Cristina, Butruille Lucile, Sébillot Anthony, LeBlay Karine, Schwaninger Markus, Heuer Heike, Demeneix Barbara A. & Remaud Sylvie, February 2021 — Absence of Both Thyroid Hormone Transporters MCT8 and OATP1C1 Impairs Neural Stem Cell Fate in the Adult Mouse Subventricular Zone. Adult neural stem cell (NSC) generation in vertebrate brains requires thyroid hormones (THs). How THs enter the NSC population… Stem Cell Reports vol. 16, n° 2, p. 337-353
ISSN
2213-6711
https://dx.doi.org/10.1016/j.stemcr.2020.12.009
Deprouw Camille, Courties Alice, Fini Jean-Baptiste, Clerget-Froidevaux Marie-Stéphanie, Demeneix Barbara, Berenbaum Francis, Sellam Jérémie & Louati Karine, June 2022 — Pollutants: a candidate as a new risk factor for osteoarthritis-results from a systematic literature review. BACKGROUND : Considering non-classical environmental risk factors for osteoarthritis (OA), a systematic literature review … RMD Open vol. 8, n° 2, e001983
ISSN
2056-5933
https://dx.doi.org/10.1136/rmdopen-2021-001983
Vancamp Pieter, Butruille Lucile, Herranen Anni, Boelen Anita, Fini Jean-Baptiste, Demeneix Barbara A. & Remaud Sylvie, January 2023 — Transient developmental exposure to low doses of bisphenol F negatively affects neurogliogenesis and olfactory behaviour in adult mice. Neural stem cells in the murine subventricular zone (SVZ) reactivate during postnatal development to generate neurons and glia… Environ Int . vol. 172, , p. 107770
ISSN
1873-6750
https://dx.doi.org/10.1016/j.envint.2023.107770
Messina Simone, Costantini David & Eens Marcel, Sci Total Environ March 2023 — Impacts of rising temperatures and water acidification on the oxidative status and immune system of aquatic ectothermic vertebrates: A meta-analysis. Species persistence in the Anthropocene is dramatically threatened by global climate change. Large emissions of carbon dioxide… vol. 868, , p. 161580
ISSN
1879-1026
https://dx.doi.org/10.1016/j.scitotenv.2023.161580
Butruille L., Jubin P., Martin E., Aigrot M. S., Lhomme M., Fini J. B., Demeneix B., Stankoff B., Lubetzki C., Zalc B. & Remaud S., September 2023 — Deleterious functional consequences of perfluoroalkyl substances accumulation into the myelin sheath. Exposure to persistent organic pollutants during the perinatal period is of particular concern because of the potential… vol. 180, , p. 108211
ISSN
1873-6750
https://dx.doi.org/10.1016/j.envint.2023.108211
Krief Sabrina, Spirhanzlova Petra, Masi Shelly, Couturier Chloé, Okwir Eric, Asalu Edward, Bustamante Paco & Costantini David, November 2023 — High urinary oxidative DNA damage in wild chimpanzees ranging in proximity of agricultural fields in Sebitoli area, Uganda. Agriculture expansion is a major cause of habitat loss and exposure to phytochemical pollution for non-human primates. In… vol. 30, n° 51, p. 110600-110611
ISSN
1614-7499
https://dx.doi.org/10.1007/s11356-023-30187-3
Butruille Lucile, Sébillot Anthony, Ávila Katia, Vancamp Pieter, Demeneix Barbara A., Pifferi Fabien & Remaud Sylvie, February 2023 — Increased oligodendrogenesis and myelination in the subventricular zone of aged mice and gray mouse lemurs. The adult rodent subventricular zone (SVZ) generates neural stem cells (NSCs) throughout life that migrate to the olfactory… Stem Cell Reports vol. 18, n° 2, p. 534-554
ISSN
2213-6711
https://dx.doi.org/10.1016/j.stemcr.2022.12.015
Vancamp Pieter & Remaud Sylvie, March 2023 — Developmental exposure to thyroid disruptors: misprogramming of the brain’s stem cells in later life?. Neural Regen Res vol. 18, n° 3, p. 527-528
ISSN
1673-5374
https://dx.doi.org/10.4103/1673-5374.346053
Butruille Lucile, Vancamp Pieter, Demeneix Barbara A. & Remaud Sylvie, 2021 — Thyroid hormone regulation of adult neural stem cell fate: A comparative analysis between rodents and primates. Thyroid hormone (TH) signaling, a highly conserved pathway across vertebrates, is crucial for brain development and function… Vitam Horm . vol. 116, , p. 133-192
ISSN
0083-6729
https://dx.doi.org/10.1016/bs.vh.2021.02.009
Vancamp Pieter, Butruille Lucile, Demeneix Barbara A. & Remaud Sylvie, 2020 — Thyroid Hormone and Neural Stem Cells: Repair Potential Following Brain and Spinal Cord Injury. Neurodegenerative diseases are characterized by chronic neuronal and/or glial cell loss, while traumatic injury is often… Front Neurosci vol. 14, , p. 875
ISSN
1662-4548
https://dx.doi.org/10.3389/fnins.2020.00875
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