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PhyMA is a laboratory under the dual supervision of the CNRS (INEE) and the National Museum of Natural History.
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Physiologie moléculaire et adaptation
UMR 7221

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Remaud Sylvie, López-Juárez Silvia Alejandra, Bolcato-Bellemin Anne-Laure, Neuberg Patrick, Stock Fabrice, Bonnet Marie-Elise, Ghaddab Rym, Clerget-Froidevaux Marie Stéphanie, Pierre-Simons Jacqueline, Erbacher Patrick, Demeneix Barbara A. & Morvan-Dubois Ghislaine, April 2013 — Inhibition of Sox2 Expression in the Adult Neural Stem Cell Niche In Vivo by Monocationic-based siRNA Delivery. Mol Ther Nucleic Acids vol. 2, , e89
ISSN
2162-2531
https://dx.doi.org/10.1038/mtna.2013.8
Vancamp Pieter, Gothié Jean-David, Luongo Cristina, Sébillot Anthony, Le Blay Karine, Butruille Lucile, Pagnin Maurice, Richardson Samantha J., Demeneix Barbara A. & Remaud Sylvie, 2019 — Gender-specific effects of transthyretin on neural stem cell fate in the subventricular zone of the adult mouse. Choroid plexus epithelial cells produce and secrete transthyretin (TTR). TTR binds and distributes thyroid hormone (TH) to… Sci Rep vol. 9, n° 1, p. 19689
ISSN
2045-2322
https://dx.doi.org/10.1038/s41598-019-56156-w
Gothié J. D., Sébillot A., Luongo C., Legendre M., Nguyen Van C., Le Blay K., Perret-Jeanneret M., Remaud S. & Demeneix B. A., 2017 — Adult neural stem cell fate is determined by thyroid hormone activation of mitochondrial metabolism. OBJECTIVE : In the adult brain, neural stem cells (NSCs) located in the subventricular zone (SVZ) produce both neuronal and… Mol Metab vol. 6, n° 11, p. 1551-1561
ISSN
2212-8778
https://dx.doi.org/10.1016/j.molmet.2017.08.003
Remaud Sylvie, Ortiz Fernando C., Perret-Jeanneret Marine, Aigrot Marie-Stéphane, Gothié Jean-David, Fekete Csaba, Kvárta-Papp Zsuzsanna, Gereben Balázs, Langui Dominique, Lubetzki Catherine, Angulo Maria Cecilia, Zalc Bernard & Demeneix Barbara, 2017 — Transient hypothyroidism favors oligodendrocyte generation providing functional remyelination in the adult mouse brain. Elife vol. 6, ,
ISSN
2050-084X
https://dx.doi.org/10.7554/eLife.29996
Gothié Jean-David, Demeneix Barbara & Remaud Sylvie, December 2017 — Comparative approaches to understanding thyroid hormone regulation of neurogenesis. Mol. Cell. Endocrinol. vol. 459, , p. 104-115
ISSN
1872-8057
https://dx.doi.org/10.1016/j.mce.2017.05.020
Remaud Sylvie, Gothié Jean-David, Morvan-Dubois Ghislaine & Demeneix Barbara A., 2014 — Thyroid hormone signaling and adult neurogenesis in mammals. Front Endocrinol (Lausanne) vol. 5, , p. 62
ISSN
1664-2392
https://dx.doi.org/10.3389/fendo.2014.00062
Remaud Sylvie, Morvan-Dubois Ghislaine & Demeneix Barbara A., December 2012 — [Thyroid hormone signalling favors neural stem cell commitment]. Med Sci (Paris) vol. 28, n° 12, p. 1050-1052
ISSN
0767-0974
https://dx.doi.org/10.1051/medsci/20122812010
López-Juárez Alejandra, Remaud Sylvie, Hassani Zahra, Jolivet Pascale, Pierre Simons Jacqueline, Sontag Thomas, Yoshikawa Kazuaki, Price Jack, Morvan-Dubois Ghislaine & Demeneix Barbara A., May 2012 — Thyroid hormone signaling acts as a neurogenic switch by repressing Sox2 in the adult neural stem cell niche. Cell Stem Cell vol. 10, n° 5, p. 531-543
ISSN
1875-9777
https://dx.doi.org/10.1016/j.stem.2012.04.008
Remaud Sylvie, Audibert Agnès & Gho Michel, 2008 — S-phase favours notch cell responsiveness in the Drosophila bristle lineage. PLoS ONE vol. 3, n° 11, e3646
ISSN
1932-6203
https://dx.doi.org/10.1371/journal.pone.0003646
Le Borgne Roland, Remaud Sylvie, Hamel Sophie & Schweisguth François, April 2005 — Two distinct E3 ubiquitin ligases have complementary functions in the regulation of delta and serrate signaling in Drosophila. PLoS Biol. vol. 3, n° 4, e96
ISSN
1545-7885
https://dx.doi.org/10.1371/journal.pbio.0030096
Vancamp Pieter, Spirhanzlova Petra, Sébillot Anthony, Butruille Lucile, Gothié Jean-David, Le Mével Sébastien, Leemans Michelle, Wejaphikul Karn, Meima Marcel, Mughal Bilal B., Roques Pierre, Remaud Sylvie, Fini Jean-Baptiste & Demeneix Barbara A., 2021 — The pyriproxyfen metabolite, 4’-OH-PPF, disrupts thyroid hormone signaling in neural stem cells, modifying neurodevelopmental genes affected by ZIKA virus infection. North-Eastern Brazil saw intensive application of the insecticide pyriproxyfen (PPF) during the microcephaly outbreak caused… Environ Pollut. vol. 285, , p. 117654
ISSN
1873-6424
https://dx.doi.org/10.1016/j.envpol.2021.117654
Kortenkamp Andreas, Axelstad Marta, Baig Asma H., Bergman Åke, Bornehag Carl-Gustaf, Cenijn Peter, Christiansen Sofie, Demeneix Barbara, Derakhshan Arash, Fini Jean-Baptiste, Frädrich Caroline, Hamers Timo, Hellwig Lina, Köhrle Josef, Korevaar Tim I. M. et al., 2020 — Removing Critical Gaps in Chemical Test Methods by Developing New Assays for the Identification of Thyroid Hormone System-Disrupting Chemicals-The ATHENA Project. The test methods that currently exist for the identification of thyroid hormone system-disrupting chemicals are woefully… Int J Mol Sci vol. 21, n° 9, E3123
ISSN
1422-0067
https://dx.doi.org/10.3390/ijms21093123
Remaud Sylvie & Demeneix Barbara, 2019 — [Thyroid hormones regulate neural stem cell fate]. Thyroid hormones (THs) are vital for vertebrate brain function throughout life, from early development to ageing… Biol Aujourdhui vol. 213, n° 1, p. 7-16
ISSN
2105-0686
https://dx.doi.org/10.1051/jbio/2019007
Gothié Jean-David, Vancamp Pieter, Demeneix Barbara & Remaud Sylvie, 2020 — Thyroid hormone regulation of neural stem cell fate: From development to ageing. In the vertebrate brain, neural stem cells (NSCs) generate both neuronal and glial cells throughout life. However, their neuro… Acta Physiol (Oxf) vol. 228, n° 1, e13316
ISSN
1748-1716
https://dx.doi.org/10.1111/apha.13316
Vancamp Pieter, Le Blay Karine, Butruille Lucile, Sébillot Anthony, Boelen Anita, Demeneix Barbara A. & Remaud Sylvie, March 2022 — Developmental thyroid disruption permanently affects the neuroglial output in the murine subventricular zone. Neural stem cells (NSCs) in the adult brain are a source of neural cells for brain injury repair. We investigated whether… Stem Cell Reports vol. 17, n° 3, p. 459-474
ISSN
2213-6711
https://dx.doi.org/10.1016/j.stemcr.2022.01.002
Luongo Cristina, Butruille Lucile, Sébillot Anthony, LeBlay Karine, Schwaninger Markus, Heuer Heike, Demeneix Barbara A. & Remaud Sylvie, February 2021 — Absence of Both Thyroid Hormone Transporters MCT8 and OATP1C1 Impairs Neural Stem Cell Fate in the Adult Mouse Subventricular Zone. Adult neural stem cell (NSC) generation in vertebrate brains requires thyroid hormones (THs). How THs enter the NSC population… Stem Cell Reports vol. 16, n° 2, p. 337-353
ISSN
2213-6711
https://dx.doi.org/10.1016/j.stemcr.2020.12.009
Vancamp Pieter, Butruille Lucile, Herranen Anni, Boelen Anita, Fini Jean-Baptiste, Demeneix Barbara A. & Remaud Sylvie, January 2023 — Transient developmental exposure to low doses of bisphenol F negatively affects neurogliogenesis and olfactory behaviour in adult mice. Neural stem cells in the murine subventricular zone (SVZ) reactivate during postnatal development to generate neurons and glia… Environ Int . vol. 172, , p. 107770
ISSN
1873-6750
https://dx.doi.org/10.1016/j.envint.2023.107770
Butruille L., Jubin P., Martin E., Aigrot M. S., Lhomme M., Fini J. B., Demeneix B., Stankoff B., Lubetzki C., Zalc B. & Remaud S., September 2023 — Deleterious functional consequences of perfluoroalkyl substances accumulation into the myelin sheath. Exposure to persistent organic pollutants during the perinatal period is of particular concern because of the potential… vol. 180, , p. 108211
ISSN
1873-6750
https://dx.doi.org/10.1016/j.envint.2023.108211
Butruille Lucile, Sébillot Anthony, Ávila Katia, Vancamp Pieter, Demeneix Barbara A., Pifferi Fabien & Remaud Sylvie, February 2023 — Increased oligodendrogenesis and myelination in the subventricular zone of aged mice and gray mouse lemurs. The adult rodent subventricular zone (SVZ) generates neural stem cells (NSCs) throughout life that migrate to the olfactory… Stem Cell Reports vol. 18, n° 2, p. 534-554
ISSN
2213-6711
https://dx.doi.org/10.1016/j.stemcr.2022.12.015
Vancamp Pieter & Remaud Sylvie, March 2023 — Developmental exposure to thyroid disruptors: misprogramming of the brain’s stem cells in later life?. Neural Regen Res vol. 18, n° 3, p. 527-528
ISSN
1673-5374
https://dx.doi.org/10.4103/1673-5374.346053
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