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PhyMA is a laboratory under the dual supervision of the CNRS (INEE) and the National Museum of Natural History.
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Physiologie moléculaire et adaptation
UMR 7221

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Porter J. F., Connor K., van der Zee A., Reubsaet F., Ibsen P., Heron I., Chaby R., Le Blay K. & Donachie W., October 1995 — Characterisation of ovine Bordetella parapertussis isolates by analysis of specific endotoxin (lipopolysaccharide) epitopes, filamentous haemagglutinin production, cellular fatty acid composition and antibiotic sensitivity. FEMS Microbiol. Lett. vol. 132, n° 3, p. 195-201
ISSN
0378-1097
https://dx.doi.org/10.1111/j.1574-6968.1995.tb07833.x
Le Blay K., Caroff M., Richards J. C., Perry M. B. & Chaby R., September 1994 — Specific and cross-reacting monoclonal antibodies to Bordetella parapertussis and Bordetella bronchiseptica lipopolysaccharides. Microbiology (Reading, Engl.) vol. 140 ( Pt 9), , p. 2459-2465
ISSN
1350-0872
https://dx.doi.org/10.1099/13500872-140-9-2459
Rose T., Glaser P., Surewicz W. K., Mantsch H. H., Reinstein J., Le Blay K., Gilles A. M. & Bârzu O., December 1991 — Structural and functional consequences of amino acid substitutions in the second conserved loop of Escherichia coli adenylate kinase. J. Biol. Chem. vol. 266, n° 35, p. 23654-23659
ISSN
0021-9258
Rose T., Brune M., Wittinghofer A., Le Blay K., Surewicz W. K., Mantsch H. H., Bârzu O. & Gilles A. M., June 1991 — Structural and catalytic properties of a deletion derivative (delta 133-157) of Escherichia coli adenylate kinase. J. Biol. Chem. vol. 266, n° 17, p. 10781-10786
ISSN
0021-9258
Lascu I., Le Blay K., Lacombe M. L., Presecan E. & Véron M., February 1993 — Assay of nucleoside diphosphate kinase in microtiter plates using a peroxidase-coupled method. Anal. Biochem. vol. 209, n° 1, p. 6-8
ISSN
0003-2697
https://dx.doi.org/10.1006/abio.1993.1075
Froidevaux Marie-Stéphanie Clerget, Berg Petra, Seugnet Isabelle, Decherf Stéphanie, Becker Nathalie, Sachs LaurentM., Bilesimo Patrice, Nygård Maria, Pongratz Ingemar & Demeneix Barbara A., October 2006 — The co-chaperone XAP2 is required for activation of hypothalamic thyrotropin-releasing hormone transcription in vivo. EMBO Rep. vol. 7, n° 10, p. 1035-1039
ISSN
1469-221X
https://dx.doi.org/10.1038/sj.embor.7400778
Vancamp Pieter, Spirhanzlova Petra, Sébillot Anthony, Butruille Lucile, Gothié Jean-David, Le Mével Sébastien, Leemans Michelle, Wejaphikul Karn, Meima Marcel, Mughal Bilal B., Roques Pierre, Remaud Sylvie, Fini Jean-Baptiste & Demeneix Barbara A., 2021 — The pyriproxyfen metabolite, 4’-OH-PPF, disrupts thyroid hormone signaling in neural stem cells, modifying neurodevelopmental genes affected by ZIKA virus infection. North-Eastern Brazil saw intensive application of the insecticide pyriproxyfen (PPF) during the microcephaly outbreak caused… Environ Pollut. vol. 285, , p. 117654
ISSN
1873-6424
https://dx.doi.org/10.1016/j.envpol.2021.117654
Gothié Jean-David, Vancamp Pieter, Demeneix Barbara & Remaud Sylvie, 2020 — Thyroid hormone regulation of neural stem cell fate: From development to ageing. In the vertebrate brain, neural stem cells (NSCs) generate both neuronal and glial cells throughout life. However, their neuro… Acta Physiol (Oxf) vol. 228, n° 1, e13316
ISSN
1748-1716
https://dx.doi.org/10.1111/apha.13316
Levi Giovanni, Narboux-Nême Nicolas & Cohen-Solal Martine, October 2022 — DLX Genes in the Development and Maintenance of the Vertebrate Skeleton: Implications for Human Pathologies. Skeletal shape and mechanical properties define, to a large extent, vertebrate morphology and physical capacities. During… Cells vol. 11, n° 20, p. 3277
ISSN
2073-4409
https://dx.doi.org/10.3390/cells11203277
Mullen Rachel D., Bellessort Brice, Levi Giovanni & Behringer Richard R., 2022 — Distal-less homeobox genes Dlx5/6 regulate Müllerian duct regression. Dlx5 and Dlx6 encode distal-less homeodomain transcription factors that are present in the genome as a linked pair at a single… Frontiers in Endocrinology vol. 13, , p. 916173
ISSN
1664-2392
https://dx.doi.org/10.3389/fendo.2022.916173
Levi Giovanni, de Lombares Camille, Giuliani Cristina, Iannuzzi Vincenzo, Aouci Rym, Garagnani Paolo, Franceschi Claudio, Grimaud-Hervé Dominique & Narboux-Nême Nicolas, 2021 — DLX 5/6 GABAergic expression affects social vocalization: implications for human evolution. DLX 5 and DLX6 are two closely related transcription factors involved in brain development and in GABAergic differentiation… Mol. Biol. Evol. , , msab181
ISSN
1537-1719
https://dx.doi.org/10.1093/molbev/msab181
Aouci Rym, El Soudany Mey, Maakoul Zakaria, Fontaine Anastasia, Kurihara Hiroki, Levi Giovanni & Narboux-Nême Nicolas, May 2022 — Dlx5/6 Expression Levels in Mouse GABAergic Neurons Regulate Adult Parvalbumin Neuronal Density and Anxiety/Compulsive Behaviours. Neuronal circuits integrating Parvalbumin-positive GABAergic inhibitory interneurons (PV) are essential for normal brain… Cells vol. 11, n° 11, p. 1739
ISSN
2073-4409
https://dx.doi.org/10.3390/cells11111739
Chamas Lamis, Seugnet Isabelle, Poirier Roseline, Clerget-Froidevaux Marie-Stéphanie & Enderlin Valérie, October 2022 — A Fine Regulation of the Hippocampal Thyroid Signalling Protects Hypothyroid Mice against Glial Cell Activation. Adult-onset hypothyroidism is associated with learning and cognitive dysfunctions, which may be related to alterations in… International Journal of Molecular Sciences vol. 23, n° 19, p. 11938
ISSN
1422-0067
https://dx.doi.org/10.3390/ijms231911938
Vancamp Pieter, Le Blay Karine, Butruille Lucile, Sébillot Anthony, Boelen Anita, Demeneix Barbara A. & Remaud Sylvie, March 2022 — Developmental thyroid disruption permanently affects the neuroglial output in the murine subventricular zone. Neural stem cells (NSCs) in the adult brain are a source of neural cells for brain injury repair. We investigated whether… Stem Cell Reports vol. 17, n° 3, p. 459-474
ISSN
2213-6711
https://dx.doi.org/10.1016/j.stemcr.2022.01.002
Valcárcel-Hernández Victor, Mayerl Steffen, Guadaño-Ferraz Ana & Remaud Sylvie, 2024 — Thyroid hormone action in adult neurogliogenic niches: the known and unknown. Over the last decades, thyroid hormones (THs) signaling has been established as a key signaling cue for the proper maintenance… Frontiers in Endocrinology vol. 15, , p. 1347802
ISSN
1664-2392
https://dx.doi.org/10.3389/fendo.2024.1347802
Valcárcel-Hernández Víctor, Vancamp Pieter, Butruille Lucile, Remaud Sylvie & Guadaño-Ferraz Ana, June 2024 — Combined deletion of Mct8 and Dio2 impairs SVZ neurogliogenesis and olfactory function in adult mice. Within the adult mouse subventricular zone (SVZ), neural stem cells (NSCs) produce neuroblasts and oligodendrocyte precursor… Neurobiology of Disease vol. 199, , p. 106572
ISSN
1095-953X
https://dx.doi.org/10.1016/j.nbd.2024.106572
Aouci Rym, Fontaine Anastasia, Vion Amïn, Belz Lou, Levi Giovanni & Narboux-Nême Nicolas, July 2024 — The Antidepressant Action of Fluoxetine Involves the Inhibition of Dlx5/6 in Cortical GABAergic Neurons through a TrkB-Dependent Pathway. Major depressive disorder (MDD) is a complex and devastating illness that affects people of all ages. Despite the large use of… Cells vol. 13, n° 15, p. 1262
ISSN
2073-4409
https://dx.doi.org/10.3390/cells13151262
Chamas Lamis, Seugnet Isabelle, Tanvé Odessa, Enderlin Valérie & Clerget-Froidevaux Marie-Stéphanie, October 2024 — The Downregulation of the Liver Lipid Metabolism Induced by Hypothyroidism in Male Mice: Metabolic Flexibility Favors Compensatory Mechanisms in White Adipose Tissue. In mammals, the maintenance of energy homeostasis relies on complex mechanisms requiring tight synchronization between… Int. J. Mol. Sci. vol. 25, n° 19, p. 10792
ISSN
1422-0067
https://dx.doi.org/10.3390/ijms251910792
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  • Gladys ALFAMA
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  • Anne BACHELOT
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  • Laurent COEN
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  • Karine LE BLAY
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