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PhyMA is a laboratory under the dual supervision of the CNRS (INEE) and the National Museum of Natural History.
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Physiologie moléculaire et adaptation
UMR 7221

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Turque Nathalie, Palmier Karima, Le Mével Sébastien, Alliot Caroline & Demeneix Barbara A., November 2005 — A rapid, physiologic protocol for testing transcriptional effects of thyroid-disrupting agents in premetamorphic Xenopus tadpoles. Environ. Health Perspect. vol. 113, n° 11, p. 1588-1593
ISSN
0091-6765
https://dx.doi.org/10.1289/ehp.7992
Trudeau Vance L., Turque Nathalie, Le Mével Sébastien, Alliot Caroline, Gallant Natacha, Coen Laurent, Pakdel Farzad & Demeneix Barbara, March 2005 — Assessment of estrogenic endocrine-disrupting chemical actions in the brain using in vivo somatic gene transfer. Environ. Health Perspect. vol. 113, n° 3, p. 329-334
ISSN
0091-6765
https://dx.doi.org/10.1289/ehp.7418
Rowe Isaline, Coen Laurent, Le Blay Karine, Le Mével Sébastien & Demeneix Barbara A., August 2002 — Autonomous regulation of muscle fibre fate during metamorphosis in Xenopus tropicalis. Dev. Dyn. vol. 224, n° 4, p. 381-390
ISSN
1058-8388
https://dx.doi.org/10.1002/dvdy.10117
Fini J. B., Le Mével S., Palmier K., Darras V. M., Punzon I., Richardson S. J., Clerget-Froidevaux M. S. & Demeneix B. A., October 2012 — Thyroid hormone signaling in the Xenopus laevis embryo is functional and susceptible to endocrine disruption. Endocrinology vol. 153, n° 10, p. 5068-5081
ISSN
1945-7170
https://dx.doi.org/10.1210/en.2012-1463
Affaticati Pierre, Le Mével Sébastien, Jenett Arnim, Rivière Laurie, Machado Elodie, Mughal Bilal B. & Fini Jean-Baptiste, 2018 — X-FaCT: Xenopus-Fast Clearing Technique. Methods Mol. Biol. vol. 1865, , p. 233-241
ISSN
1940-6029
https://dx.doi.org/10.1007/978-1-4939-8784-9_16
Mughal Bilal B., Leemans Michelle, Lima de Souza Elaine C., le Mevel Sébastien, Spirhanzlova Petra, Visser Theo J., Fini Jean-Baptiste & Demeneix Barbara A., 2017 — Functional Characterization of Xenopus Thyroid Hormone Transporters mct8 and oatp1c1. Endocrinology vol. 158, n° 8, p. 2694-2705
ISSN
1945-7170
https://dx.doi.org/10.1210/en.2017-00108
Fini Jean-Baptiste, Mughal Bilal B., Le Mével Sébastien, Leemans Michelle, Lettmann Mélodie, Spirhanzlova Petra, Affaticati Pierre, Jenett Arnim & Demeneix Barbara A., 2017 — Human amniotic fluid contaminants alter thyroid hormone signalling and early brain development in Xenopus embryos. Sci Rep vol. 7, , p. 43786
ISSN
2045-2322
https://dx.doi.org/10.1038/srep43786
Coen L., Kissa K., le Mevel S., Brulet P. & Demeneix B.A., November 1999 — A somatic gene transfer approach using recombinant fusion proteins to map muscle-motoneuron projections in Xenopus spinal cord. Int. J. Dev. Biol. vol. 43, n° 8, p. 823-830
ISSN
0214-6282
Ouatas T., Le Mével S., Demeneix B. A. & de Luze A., November 1998 — T3-dependent physiological regulation of transcription in the Xenopus tadpole brain studied by polyethylenimine based in vivo gene transfer. Int. J. Dev. Biol. vol. 42, n° 8, p. 1159-1164
ISSN
0214-6282
Punzon I., Latapie V., Le Mével S., Hagneau A., Jolivet P., Palmier K., Fini J. B. & Demeneix B. A., July 2013 — Towards a humanized PPARγ reporter system for in vivo screening of obesogens. Mol. Cell. Endocrinol. vol. 374, 1-2, p. 1-9
ISSN
1872-8057
https://dx.doi.org/10.1016/j.mce.2013.04.004
Fini Jean-Baptiste, Riu Anne, Debrauwer Laurent, Hillenweck Anne, Le Mével Sébastien, Chevolleau Sylvie, Boulahtouf Abdelaye, Palmier Karima, Balaguer Patrick, Cravedi Jean-Pierre, Demeneix Barbara A. & Zalko Daniel, February 2012 — Parallel biotransformation of tetrabromobisphenol A in Xenopus laevis and mammals: Xenopus as a model for endocrine perturbation studies. Toxicol. Sci. vol. 125, n° 2, p. 359-367
ISSN
1096-0929
https://dx.doi.org/10.1093/toxsci/kfr312
Fini Jean-Baptiste, Pallud-Mothré Sophie, Le Mével Sébastien, Palmier Karima, Havens Christopher M., Le Brun Matthieu, Mataix Vincent, Lemkine Gregory F., Demeneix Barbara A., Turque Nathalie & Johnson Paul E., December 2009 — An innovative continuous flow system for monitoring heavy metal pollution in water using transgenic Xenopus laevis tadpoles. Environ. Sci. Technol. vol. 43, n° 23, p. 8895-8900
ISSN
0013-936X
https://dx.doi.org/10.1021/es9008954
Fini Jean-Baptiste, Le Mevel Sebastien, Turque Nathalie, Palmier Karima, Zalko Daniel, Cravedi Jean-Pierre & Demeneix Barbara A., August 2007 — An in vivo multiwell-based fluorescent screen for monitoring vertebrate thyroid hormone disruption. Environ. Sci. Technol. vol. 41, n° 16, p. 5908-5914
ISSN
0013-936X
Coen L., du Pasquier D., Le Mevel S., Brown S., Tata J., Mazabraud A. & Demeneix B. A., July 2001 — Xenopus Bcl-X(L) selectively protects Rohon-Beard neurons from metamorphic degeneration. Proc. Natl. Acad. Sci. U.S.A. vol. 98, n° 14, p. 7869-7874
ISSN
0027-8424
https://dx.doi.org/10.1073/pnas.141226798
Havis Emmanuelle, Le Mevel Sébastien, Morvan Dubois Ghislaine, Shi De-Li, Scanlan Thomas S., Demeneix Barbara A. & Sachs Laurent M., October 2006 — Unliganded thyroid hormone receptor is essential for Xenopus laevis eye development. EMBO J. vol. 25, n° 20, p. 4943-4951
ISSN
0261-4189
https://dx.doi.org/10.1038/sj.emboj.7601356
Sachs Laurent M., Le Mevel Sébastien & Demeneix Barbara A., December 2004 — Implication of bax in Xenopus laevis tail regression at metamorphosis. Dev. Dyn. vol. 231, n° 4, p. 671-682
ISSN
1058-8388
https://dx.doi.org/10.1002/dvdy.20166
Bilesimo Patrice, Jolivet Pascale, Alfama Gladys, Buisine Nicolas, Le Mevel Sebastien, Havis Emmanuelle, Demeneix Barbara A. & Sachs Laurent M., February 2011 — Specific histone lysine 4 methylation patterns define TR-binding capacity and differentiate direct T3 responses. Mol. Endocrinol. vol. 25, n° 2, p. 225-237
ISSN
1944-9917
https://dx.doi.org/10.1210/me.2010-0269
Vancamp Pieter, Spirhanzlova Petra, Sébillot Anthony, Butruille Lucile, Gothié Jean-David, Le Mével Sébastien, Leemans Michelle, Wejaphikul Karn, Meima Marcel, Mughal Bilal B., Roques Pierre, Remaud Sylvie, Fini Jean-Baptiste & Demeneix Barbara A., 2021 — The pyriproxyfen metabolite, 4’-OH-PPF, disrupts thyroid hormone signaling in neural stem cells, modifying neurodevelopmental genes affected by ZIKA virus infection. North-Eastern Brazil saw intensive application of the insecticide pyriproxyfen (PPF) during the microcephaly outbreak caused… Environ Pollut. vol. 285, , p. 117654
ISSN
1873-6424
https://dx.doi.org/10.1016/j.envpol.2021.117654
Delfosse Vanessa, Huet Tiphaine, Harrus Deborah, Granell Meritxell, Bourguet Maxime, Gardia-Parège Caroline, Chiavarina Barbara, Grimaldi Marina, Le Mével Sébastien, Blanc Pauline, Huang David, Gruszczyk Jakub, Demeneix Barbara, Cianférani Sarah, Fini Jean-Baptiste et al., 2021 — Mechanistic insights into the synergistic activation of the RXR-PXR heterodimer by endocrine disruptor mixtures. Humans are chronically exposed to mixtures of xenobiotics referred to as endocrine-disrupting chemicals (EDCs). A vast body of… Proc Natl Acad Sci USA vol. 118, n° 1, e2020551118
ISSN
1091-6490
https://dx.doi.org/10.1073/pnas.2020551118
Tostivint Hervé, Alejevski Faredin, Leemans Michelle, Gaillard Anne-Laure, Le Mével Sébastien, Herrel Anthony, Fini Jean-Baptiste & Pézeron Guillaume, January 2022 — [Neuropeptides involved in proper spine morphogenesis: Lessons from fish and toad]. Médecine Sciences vol. 38, n° 1, p. 27-29
ISSN
1958-5381
https://dx.doi.org/10.1051/medsci/2021236
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